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The voltage-gated proton channel Hv1 promotes microglia-astrocyte communication and neuropathic pain after peripheral nerve injury
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Peng, Jiyun | - |
dc.contributor.author | Yi, Min-Hee | - |
dc.contributor.author | Jeong, Heejin | - |
dc.contributor.author | McEwan, Przemyslaw P. | - |
dc.contributor.author | Zheng, Jiaying | - |
dc.contributor.author | Wu, Gongxiong | - |
dc.contributor.author | Ganatra, Shashank | - |
dc.contributor.author | Ren, Yi | - |
dc.contributor.author | Richardson, Jason R. | - |
dc.contributor.author | Oh, Seog Bae | - |
dc.contributor.author | Wu, Long-Jun | - |
dc.date.accessioned | 2021-08-19T07:32:48Z | - |
dc.date.available | 2021-08-19T16:52:26Z | - |
dc.date.issued | 2021-06-28 | - |
dc.identifier.citation | Molecular Brain. 2021 Jun 28;14(1):99 | ko_KR |
dc.identifier.issn | 1756-6606 | - |
dc.identifier.uri | https://hdl.handle.net/10371/174804 | - |
dc.description.abstract | Activation of spinal cord microglia contributes to the development of peripheral nerve injury-induced neuropathic pain. However, the molecular mechanisms underlying microglial function in neuropathic pain are not fully understood. We identified that the voltage-gated proton channel Hv1, which is functionally expressed in spinal microglia, was significantly increased after spinal nerve transection (SNT). Hv1 mediated voltage-gated proton currents in spinal microglia and mice lacking Hv1 (Hv1 KO) display attenuated pain hypersensitivities after SNT compared with wildtype (WT) mice. In addition, microglial production of reactive oxygen species (ROS) and subsequent astrocyte activation in the spinal cord was reduced in Hv1 KO mice after SNT. Cytokine screening and immunostaining further revealed that IFN-γ expression was compromised in spinal astrocytes in Hv1 KO mice. These results demonstrate that Hv1 proton channel contributes to microglial ROS production, astrocyte activation, IFN-γ upregulation, and subsequent pain hypersensitivities after SNT. This study suggests Hv1-dependent microglia-astrocyte communication in pain hypersensitivities and identifies Hv1 as a novel therapeutic target for alleviating neuropathic pain. | ko_KR |
dc.description.sponsorship | The work was supported by the National Institutes of Health grants (R01NS110825 and R01NS088627) to L.J.W and National Research Founda‑tion of Korea grants (NRF-2017M3C7A1025602, 2018R1A5A2024418 and 2021R1A2C3003334) from Korean government MSIT (Ministry of Science and ICT) to S.B.O. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BMC | ko_KR |
dc.subject | Microglia | - |
dc.subject | Hv1 proton channel | - |
dc.subject | Hvcn1 | - |
dc.subject | Reactive oxygen species | - |
dc.subject | IFN-γ | - |
dc.subject | Microglia-astrocyte interaction | - |
dc.subject | Peripheral nerve injury | - |
dc.subject | Neuropathic pain | - |
dc.title | The voltage-gated proton channel Hv1 promotes microglia-astrocyte communication and neuropathic pain after peripheral nerve injury | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 팽지윤 | - |
dc.contributor.AlternativeAuthor | 이민희 | - |
dc.contributor.AlternativeAuthor | 정희진 | - |
dc.contributor.AlternativeAuthor | 오석배 | - |
dc.identifier.doi | 10.1186/s13041-021-00812-8 | - |
dc.citation.journaltitle | Molecular Brain | ko_KR |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s) | - |
dc.date.updated | 2021-07-04T03:21:29Z | - |
dc.citation.number | 1 | ko_KR |
dc.citation.startpage | 99 | ko_KR |
dc.citation.volume | 14 | ko_KR |
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