Browse

Kdm3b haploinsufficiency impairs the consolidation of cerebellum-dependent motor memory in mice

Cited 0 time in Web of Science Cited 0 time in Scopus
Issue Date
2021-07-03
Publisher
BMC
Citation
Molecular Brain. 2021 Jul 03;14(1):106
Keywords
Kdm3bOptokinetic response (OKR)Histone modifcationCerebellum
Abstract
Histone modifications are a key mechanism underlying the epigenetic regulation of gene expression, which is critically involved in the consolidation of multiple forms of memory. However, the roles of histone modifications in cerebellum-dependent motor learning and memory are not well understood. To test whether changes in histone methylation are involved in cerebellar learning, we used heterozygous Kdm3b knockout (Kdm3b+/−) mice, which show reduced lysine 9 on histone 3 (H3K9) demethylase activity. H3K9 di-methylation is significantly increased selectively in the granule cell layer of the cerebellum of Kdm3b+/− mice. In the cerebellum-dependent optokinetic response (OKR) learning, Kdm3b+/− mice show deficits in memory consolidation, whereas they are normal in basal oculomotor performance and OKR acquisition. In addition, RNA-seq analyses revealed that the expression levels of several plasticity-related genes were altered in the mutant cerebellum. Our study suggests that active regulation of histone methylation is critical for the consolidation of cerebellar motor memory.
ISSN
1756-6606
Language
English
URI
https://hdl.handle.net/10371/174805
DOI
https://doi.org/10.1186/s13041-021-00815-5
Files in This Item:
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Dept. of Physiology (생리학교실)Journal Papers (저널논문_생리학교실)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse