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Kdm3b haploinsufficiency impairs the consolidation of cerebellum-dependent motor memory in mice
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- Authors
- Issue Date
- 2021-07-03
- Publisher
- BMC
- Citation
- Molecular Brain. 2021 Jul 03;14(1):106
- Keywords
- Kdm3b ; Optokinetic response (OKR) ; Histone modifcation ; Cerebellum
- Abstract
- Histone modifications are a key mechanism underlying the epigenetic regulation of gene expression, which is critically involved in the consolidation of multiple forms of memory. However, the roles of histone modifications in cerebellum-dependent motor learning and memory are not well understood. To test whether changes in histone methylation are involved in cerebellar learning, we used heterozygous Kdm3b knockout (Kdm3b+/−) mice, which show reduced lysine 9 on histone 3 (H3K9) demethylase activity. H3K9 di-methylation is significantly increased selectively in the granule cell layer of the cerebellum of Kdm3b+/− mice. In the cerebellum-dependent optokinetic response (OKR) learning, Kdm3b+/− mice show deficits in memory consolidation, whereas they are normal in basal oculomotor performance and OKR acquisition. In addition, RNA-seq analyses revealed that the expression levels of several plasticity-related genes were altered in the mutant cerebellum. Our study suggests that active regulation of histone methylation is critical for the consolidation of cerebellar motor memory.
- ISSN
- 1756-6606
- Language
- English
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