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Plasma amyloid-β oligomerization assay as a pre-screening test for amyloid status
DC Field | Value | Language |
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dc.contributor.author | Babapour Mofrad, Rosha | - |
dc.contributor.author | Scheltens, Philip | - |
dc.contributor.author | Kim, SangYun | - |
dc.contributor.author | Kang, Sungmin | - |
dc.contributor.author | Youn, Young Chul | - |
dc.contributor.author | An, Seong Soo. A. | - |
dc.contributor.author | Tomassen, Jori | - |
dc.contributor.author | van Berckel, Bart N. M. | - |
dc.contributor.author | Visser, Pieter J. | - |
dc.contributor.author | van der Flier, Wiesje M. | - |
dc.contributor.author | Teunissen, Charlotte E. | - |
dc.date.accessioned | 2021-08-23T07:46:52Z | - |
dc.date.available | 2021-08-23T16:48:57Z | - |
dc.date.issued | 2021-07-26 | - |
dc.identifier.citation | Alzheimer's Research & Therapy. 2021 Jul 26;13(1):133 | ko_KR |
dc.identifier.issn | 1758-9193 | - |
dc.identifier.uri | https://hdl.handle.net/10371/174829 | - |
dc.description.abstract | Objective
We assessed the performance of plasma amyloid oligomerization tendency (OAβ) as a marker for abnormal amyloid status. Additionally, we examined long-term storage effects on plasma OAβ. Methods We included 399 subjects regardless of clinical diagnosis from the Amsterdam Dementia Cohort and European Medical Information Framework for AD project (age, 63.8 ± 6.6; 44% female). Amyloid status was determined by visual read on positron emission tomography (PET; nabnormal = 206). Plasma OAβ was measured using the multimer detection system (MDS). Long-term storage effects on MDS-OAβ were assessed using general linear models. Associations between plasma MDS-OAβ and Aβ-PET status were assessed using logistic regression and receiver operating characteristics analyses. Correlations between plasma MDS-OAβ and CSF biomarker levels were evaluated using Pearson correlation analyses. Results MDS-OAβ was higher in individuals with abnormal amyloid, and it identified abnormal Aβ-PET with an area under the curve (AUC) of 0.74 (95% CI, 0.67–0.81), especially in samples with a storage duration < 4 years. Combining APOEe4 and age with plasma MDS-OAβ revealed an AUC of 81% for abnormal amyloid PET status (95% CI, 74–87%). Plasma MDS-OAβ correlated negatively with MMSE (r = − 0.29, p < .01) and CSF Aβ42 (r = − 0.20, p < 0.05) and positively with CSF Tau (r = 0.20, p = 0.01). Conclusions Plasma MDS-OAβ combined with APOEe4 and age accurately identifies brain amyloidosis in a large Aβ-confirmed population. Using plasma MDS-OAβ as a screener reduced the costs and number of PET scans needed to screen for amyloidosis, which is relevant for clinical trials. Additionally, plasma MDS-OAβ levels appeared affected by long-term storage duration, which could be of interest for others measuring plasma Aβ biomarkers. | ko_KR |
dc.description.sponsorship | The Alzheimer Center Amsterdam is supported by Stichting Alzheimer Nederland and Stichting VUmc fonds. Research of the Alzheimer center Amsterdam is part of the neurodegeneration research program of Amsterdam Neuroscience. The clinical database structure was developed with funding from Stichting Dioraphte. The VUmc Biobank is supported by VUmc. The research leading to these results has received support from the Innovative Medicines Initiative Joint Undertaking under EMIF grant agreement no. 115372, resources of which are composed of financial contribution from the European Unions Seventh Framework Programme
(FP7/2007-2013) and EFPIA companies in kind contribution. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BMC | ko_KR |
dc.subject | Blood-based biomarker | - |
dc.subject | Plasma Aβ oligomer | - |
dc.subject | Amyloid status | - |
dc.subject | Multimer detection system | - |
dc.subject | Long-term storage | - |
dc.title | Plasma amyloid-β oligomerization assay as a pre-screening test for amyloid status | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 김상윤 | - |
dc.contributor.AlternativeAuthor | 강성민 | - |
dc.contributor.AlternativeAuthor | 윤영철 | - |
dc.contributor.AlternativeAuthor | 안성수 | - |
dc.identifier.doi | 10.1186/s13195-021-00873-w | - |
dc.citation.journaltitle | Alzheimer's Research & Therapy | ko_KR |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s) | - |
dc.date.updated | 2021-08-01T03:17:03Z | - |
dc.citation.number | 1 | ko_KR |
dc.citation.startpage | 133 | ko_KR |
dc.citation.volume | 13 | ko_KR |
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