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Comparison of demineralized bone matrix and hydroxyapatite as carriers of Escherichia coli recombinant human BMP-2

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Authors
Jin, Yuan-Zhe; Zheng, Guang-Bin; Lee, Jae Hyup; Han, Shi-Huan
Issue Date
2021-08-03
Publisher
BMC
Citation
Biomaterials Research. 2021 Aug 03;25(1):25
Keywords
Bone morphogenetic protein-2Demineralized bone matrixHydroxyapatiteCarrierBone regeneration
Abstract
Background
Autograft has been widely used in various orthopedic and dental surgery for its superior osteogenicity, osteoinductivity and osteoconductivity. But the available volume of the autograft is limited and the efficacy of it is highly affected by the condition of the patients. Therefore, growth factors such as Escherichia coli bone morphogenetic protein-2 (ErhBMP-2) has been widely used in some countries and regions with various carriers that could affect the effects of the growth factors. Demineralized bone matrix (DBM) has been widely used as a bone graft substitute and growth factor carrier, but its effect as a carrier of ErhBMP-2 was less investigated.

Materials and methods
Rat calvaria defect model was used in this study. We implanted ErhBMP-2 with DBM or hydroxyapatite (HA) as a carrier in 8 mm calvaria defect and compared their bone regeneration effect in 4th week and 8th week after implantation with micro-CT and histology. The data was analyzed with one-way ANOVA method with Bonferroni post-hoc analysis.

Result
The group with DBM as the carrier showed significantly higher bone volume and bone thickness than the groups with HA as the carrier in both weeks. And the histology sections showed less adipose tissue formed in the groups with DBM as the carrier.

Conclusion
DBM could be a better carrier for ErhBMP-2 than HA.
ISSN
2055-7124
Language
English
URI
https://hdl.handle.net/10371/174840
DOI
https://doi.org/10.1186/s40824-021-00225-7
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College of Medicine/School of Medicine (의과대학/대학원)Orthopedic Surgery (정형외과학전공)Journal Papers (저널논문_정형외과학전공)
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