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Prognostic significance of the postoperative prognostic nutritional index in patients with glioblastoma: a retrospective study

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dc.contributor.authorKim, Yoon Jung.-
dc.contributor.authorOh, Hyongmin-
dc.contributor.authorLee, Sang Jin.-
dc.contributor.authorKim, Kyung-Min-
dc.contributor.authorKang, Ho-
dc.contributor.authorPark, Chul-Kee-
dc.contributor.authorPark, Hee-Pyoung-
dc.date.accessioned2021-09-01T06:33:58Z-
dc.date.available2021-09-01T15:35:37Z-
dc.date.issued2021-08-21-
dc.identifier.citationBMC Cancer. 2021 Aug 21;21(1):942ko_KR
dc.identifier.urihttps://hdl.handle.net/10371/174853-
dc.description.abstractAbstract

Background
The prognostic nutritional index (PNI) reflects immunonutritional status. We evaluated the effects of postoperative PNI and perioperative changes in the PNI on overall survival (OS) in glioblastoma (GBM) patients.


Methods
Demographic, laboratory, and clinical data were retrospectively collected from 335 GBM patients. Preoperative and postoperative PNIs were calculated from serum albumin concentration and lymphocyte count, which were measured within 3 weeks before surgery and 1 month after surgery. Patients were classified into high (n = 206) or low (n = 129) postoperative PNI groups according to the postoperative PNI cutoff value and further classified into four groups according to the cutoff values of the preoperative and postoperative PNIs, as follows: Group HH (both high PNIs, n = 92), Group HL (high preoperative and low postoperative PNI, n = 70), Group LH (low preoperative and high postoperative PNI, n = 37), and Group LL (both low PNIs, n = 136).


Results
The median OS was significantly longer in the high postoperative PNI (PNI ≥ 50.2) group than the low postoperative PNI (PNI < 50.2) group (24.0 vs. 15.0 months, p < 0.001). In multivariate analysis, high postoperative PNI was a significant predictor of OS. OS was significantly longer in Group HH than in Group LL and seemed longer in Group HH than in Group HL and in Group LH than in Group LL. OS was not different between Groups HH and LH or between Groups HL and LL.


Conclusions
High postoperative PNI was associated with improved OS and perioperative changes in PNI may provide additional important information for prognostic prediction in GBM patients.
ko_KR
dc.language.isoenko_KR
dc.publisherBMCko_KR
dc.subjectPrognostic nutritional index-
dc.subjectGlioblastoma-
dc.subjectOverall survival-
dc.subjectSurgery-
dc.titlePrognostic significance of the postoperative prognostic nutritional index in patients with glioblastoma: a retrospective studyko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor김윤정-
dc.identifier.doihttps://doi.org/10.1186/s12885-021-08686-8-
dc.citation.journaltitleBMC Cancerko_KR
dc.language.rfc3066en-
dc.rights.holderThe Author(s)-
dc.date.updated2021-08-22T03:11:41Z-
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