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Impact of very preterm birth and post-discharge growth on cardiometabolic outcomes at school age: a retrospective cohort study
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yun, Jungha | - |
dc.contributor.author | Jung, Young Hwa | - |
dc.contributor.author | Shin, Seung Han | - |
dc.contributor.author | Song, In Gyu | - |
dc.contributor.author | Lee, Young Ah | - |
dc.contributor.author | Shin, Choong Ho | - |
dc.contributor.author | Kim, Ee-Kyung | - |
dc.contributor.author | Kim, Han-Suk | - |
dc.date.accessioned | 2021-09-15T01:45:18Z | - |
dc.date.available | 2021-09-15T10:49:07Z | - |
dc.date.issued | 2021-08-31 | - |
dc.identifier.citation | BMC Pediatrics. 2021 Aug 31;21(1):373 | ko_KR |
dc.identifier.issn | 1471-2431 | - |
dc.identifier.uri | https://hdl.handle.net/10371/174878 | - |
dc.description.abstract | Background
Adverse metabolic outcomes later in life have been reported among children or young adults who were born as preterm infants. This study was conducted to examine the impact of very preterm/very low birth weight (VP/VLBW) birth and subsequent growth after hospital discharge on cardiometabolic outcomes such as insulin resistance, fasting glucose, and systolic and diastolic blood pressure (BP) among children at 6–8 years of age. Methods This retrospective cohort study included children aged 6–8 years and compared those who were born at < 32 weeks of gestation or weighing < 1,500g at birth (n = 60) with those born at term (n = 110). Body size, fat mass, BP, glucose, insulin, leptin, adiponectin, and lipid profiles were measured. Weight-for-age z-score changes between discharge and early school-age period were also calculated, and factors associated with BP, fasting glucose, and insulin resistance were analyzed. Results Children who were born VP/VLBW had significantly lower fat masses, higher systolic BP and diastolic BP, and significantly higher values of fasting glucose, insulin, and homeostatic model assessment of insulin resistance (HOMA-IR), compared to children born at term. VP/VLBW was correlated with HOMA-IR and BPs after adjusting for various factors, including fat mass index and weight-for-age z-score changes. Weight-for-age z-score changes were associated with HOMA-IR, but not with BPs. Conclusions Although children aged 6–8 years who were born VP/VLBW showed significantly lower weight and fat mass, they had significantly higher BPs, fasting glucose, HOMA-IR, and leptin levels. The associations of VP/VLBW with cardiometabolic factors were independent of fat mass and weight gain velocity. | ko_KR |
dc.description.sponsorship | This research was supported by a grant from the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHID I), funded by the Ministry of Health & Welfare, Republic of Korea (HI14C3451). | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BMC | ko_KR |
dc.subject | Very preterm infants | - |
dc.subject | Insulin resistance | - |
dc.subject | Hypertension | - |
dc.subject | Growth | - |
dc.title | Impact of very preterm birth and post-discharge growth on cardiometabolic outcomes at school age: a retrospective cohort study | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 윤정하 | - |
dc.contributor.AlternativeAuthor | 정영화 | - |
dc.contributor.AlternativeAuthor | 신승한 | - |
dc.contributor.AlternativeAuthor | 송인규 | - |
dc.contributor.AlternativeAuthor | 이영아 | - |
dc.contributor.AlternativeAuthor | 신충호 | - |
dc.contributor.AlternativeAuthor | 김애경 | - |
dc.contributor.AlternativeAuthor | 김한석 | - |
dc.identifier.doi | 10.1186/s12887-021-02851-5 | - |
dc.citation.journaltitle | BMC Pediatrics | ko_KR |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s) | - |
dc.date.updated | 2021-09-05T03:10:43Z | - |
dc.citation.number | 1 | ko_KR |
dc.citation.startpage | 373 | ko_KR |
dc.citation.volume | 21 | ko_KR |
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