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The relationship between the effect-site concentration of propofol and sedation scale in children: a pharmacodynamic modeling study
DC Field | Value | Language |
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dc.contributor.author | Jang, Young-Eun | - |
dc.contributor.author | Ji, Sang-Hwan | - |
dc.contributor.author | Lee, Ji-Hyun | - |
dc.contributor.author | Kim, Eun-Hee | - |
dc.contributor.author | Kim, Jin-Tae | - |
dc.contributor.author | Kim, Hee-Soo | - |
dc.date.accessioned | 2021-09-27T06:57:52Z | - |
dc.date.available | 2021-09-27T15:59:20Z | - |
dc.date.issued | 2021-09-09 | - |
dc.identifier.citation | BMC Anesthesiology. 2021 Sep 09;21(1):222 | ko_KR |
dc.identifier.issn | 1471-2253 | - |
dc.identifier.uri | https://hdl.handle.net/10371/174894 | - |
dc.description.abstract | Background
Continuous infusion of propofol has been used to achieve sedation in children. However, the relationship between the effect-site concentration (Ce) of propofol and sedation scale has not been previously examined. The objective of this study was to investigate the relationship between the Ce of propofol and the University of Michigan Sedation Scale (UMSS) score in children with population pharmacodynamic modeling. Methods A total of 30 patients (aged 3 to 6 years) who underwent surgery under general anesthesia with propofol and remifentanil lasting more than 1 h were enrolled in this study. Sedation levels were evaluated using the UMSS score every 20 s by a 1 μg/mL stepwise increase in the Ce of propofol during the induction of anesthesia. The pharmacodynamic relationship between the Ce of propofol and UMSS score was analyzed by logistic regression with nonlinear mixed-effect modeling. Results The estimated Ce50 (95% confidence interval) of propofol to yield UMSS scores equal to or greater than n were 1.84 (1.54–2.14), 2.64 (2.20–3.08), 3.98 (3.66–4.30), and 4.78 (4.53–5.03) μg/mL for n = 1, 2, 3, and 4, respectively. The slope steepness for the relationship of the Ce versus sedative response to propofol (95% confidence interval) was 5.76 (4.00–7.52). Conclusions We quantified the pharmacodynamic relationship between the Ce of propofol and UMSS score, and this finding may be helpful to predict the sedation score at the target Ce of propofol in children. Trial registration http://www.clinicaltrials.gov (No.: NCT03195686 , Date of registration: 22/06/2017). | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BMC | ko_KR |
dc.subject | Anesthesia | - |
dc.subject | Anesthetics | - |
dc.subject | Pharmacodynamics | - |
dc.subject | Pharmacokinetics | - |
dc.subject | Sedation | - |
dc.title | The relationship between the effect-site concentration of propofol and sedation scale in children: a pharmacodynamic modeling study | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 장영은 | - |
dc.contributor.AlternativeAuthor | 지상환 | - |
dc.contributor.AlternativeAuthor | 이지현 | - |
dc.contributor.AlternativeAuthor | 김은희 | - |
dc.contributor.AlternativeAuthor | 김진태 | - |
dc.contributor.AlternativeAuthor | 김희수 | - |
dc.identifier.doi | https://doi.org/10.1186/s12871-021-01446-y | - |
dc.citation.journaltitle | BMC Anesthesiology | ko_KR |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s) | - |
dc.date.updated | 2021-09-12T03:08:06Z | - |
dc.citation.number | 1 | ko_KR |
dc.citation.startpage | 222 | ko_KR |
dc.citation.volume | 21 | ko_KR |
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