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Pharmacokinetics of 5-[2-propyloxy-5-(1-methy1-2-pyrollidinylethylamidosulphonyl)phenyl]-1-methyl-3-propyl-1, 6-dihydro-7H-pyrazolo(4,3-d)pyrimidine-7-one), a new phosphodiesterase type V inhibitor
새로운 포스포디에스터라제 V 저해제, 5-[2-propyloxy-5-(1-methyl-2-pyrollidinylethylamidosulphony1)phenyl]-1-methyl-3-propyl-1, 6-dihydro-7H-pyrazolo(4,3-d)pyrimidine-7-one)의 약물역학에 관한 연구
- Authors
- 심현주
- Advisor
- 이명걸
- Issue Date
- 2005
- Publisher
- 서울대학교 대학원
- Keywords
- DA-8159; DA-8159; DA-8164; DA-8164; 고속액체크로마토그라피; High performance liquid chromatography; 안정성; Stability; 혈액분배; Blood partition; 단백결합; Protein binding; 약물역학; Pharmacokinetics; 간 및 소장 초회통과효과; Hepatic and intestinal first pass effects; 대사효소 유도제 및 저해제; Enzyme inducers and inhibitors; 독성동태학; Toxicokinetics; 종간 차이; Species differences; animal scale-up; Interspecies scaling; 단백질-칼로리영양결핍 랫드; Protein calorie malnutrition; uranyl nitrate로 유도한 급성신부전 랫드; Uranyl nitrate-induced acute renal failure.
- Description
- Thesis(doctoral)--서울대학교 대학원 :약학과 약물학전공,2005.
- Language
- English
- URI
- http://dcollection.snu.ac.kr:80/jsp/common/DcLoOrgPer.jsp?sItemId=000000050002
http://hdl.handle.net/10371/17536
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- Appears in Collections:
- College of Pharmacy (약학대학)Dept. of Pharmacy (약학과)Theses (Ph.D. / Sc.D._약학과)
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