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Treatment outcomes of re-irradiation using stereotactic ablative radiotherapy to lung: a propensity score matching analysis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Tae Hoon | - |
dc.contributor.author | Kim, Dong-Yun | - |
dc.contributor.author | Wu, Hong-Gyun | - |
dc.contributor.author | Lee, Joo Ho | - |
dc.contributor.author | Kim, Hak Jae | - |
dc.date.accessioned | 2022-03-04T05:59:59Z | - |
dc.date.available | 2022-03-04T05:59:59Z | - |
dc.date.issued | 2021-11-18 | - |
dc.identifier.citation | Radiation Oncology. 2021 Nov 18;16(1):222 | ko_KR |
dc.identifier.issn | 1748-717X | - |
dc.identifier.uri | https://hdl.handle.net/10371/176998 | - |
dc.description.abstract | Background
The purpose of this study was to compare the treatment efficacy and safety of re-irradiation (re-RT) using stereotactic ablative radiotherapy (SABR) and initial SABR for primary, recurrent lung cancer or metastatic lung tumor. Methods A retrospective review of the medical records of 336 patients who underwent lung SABR was performed. Re-RT was defined as the overlap of the 70% isodose line of second-course SABR with that of the initial radiotherapy, and 20 patients were classified as the re-RT group. The median dose of re-RT using SABR was 54Gy (range 48–60Gy), and the median fraction number was 4 (range 4–6). One-to-three case-matched analysis with propensity score matching was used, and 60 patients were included in the initial SABR group of the matched cohort. Results The 1- and 2-year local control rates for the re-RT group were 73.9% and 63.3% and those for the initial SABR group in the matched cohort were 92.9% and 87.7%, respectively (P = 0.013). There was no difference in distant metastasis-free, progression-free, and overall survival rates. The crude grade ≥ 2 toxicity rates were 40.0% for the re-RT group and 25.0% for the initial SABR group (P = 0.318). Re-RT group had higher acute grade ≥ 2 toxicity rates (25.0% vs 5.0%, P = 0.031). One incident of grade 3 toxicity (pulmonary) was reported in the re-RT group; there was no grade 4‒5 toxicity. Conclusions The local control rate of the in-field re-RT SABR was lower than that of the initial SABR without compromising the survival rates. The toxicity of re-RT using SABR was acceptable. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BMC | ko_KR |
dc.subject | Lung cancer | - |
dc.subject | Metastasis | - |
dc.subject | Stereotactic radiation therapy | - |
dc.subject | Re-irradiation | - |
dc.title | Treatment outcomes of re-irradiation using stereotactic ablative radiotherapy to lung: a propensity score matching analysis | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 이태훈 | - |
dc.contributor.AlternativeAuthor | 김동윤 | - |
dc.contributor.AlternativeAuthor | 우홍균 | - |
dc.contributor.AlternativeAuthor | 이주호 | - |
dc.contributor.AlternativeAuthor | 김학재 | - |
dc.identifier.doi | https://doi.org/10.1186/s13014-021-01948-6 | - |
dc.citation.journaltitle | Radiation Oncology | ko_KR |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s) | - |
dc.date.updated | 2021-11-21T04:21:57Z | - |
dc.citation.number | 1 | ko_KR |
dc.citation.startpage | 222 | ko_KR |
dc.citation.volume | 16 | ko_KR |
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