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Causal effects of atrial fibrillation on brain white and gray matter volume: a Mendelian randomization study
DC Field | Value | Language |
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dc.contributor.author | Park, Sehoon | - |
dc.contributor.author | Lee, Soojin | - |
dc.contributor.author | Kim, Yaerim | - |
dc.contributor.author | Cho, Semin | - |
dc.contributor.author | Kim, Kwangsoo | - |
dc.contributor.author | Kim, Yong Chul | - |
dc.contributor.author | Han, Seung Seok | - |
dc.contributor.author | Lee, Hajeong | - |
dc.contributor.author | Lee, Jung Pyo | - |
dc.contributor.author | Lee, Soryoung | - |
dc.contributor.author | Choi, Eue-Keun | - |
dc.contributor.author | Joo, Kwon Wook | - |
dc.contributor.author | Lim, Chun Soo | - |
dc.contributor.author | Kim, Yon Su | - |
dc.contributor.author | Kim, Dong Ki | - |
dc.date.accessioned | 2022-03-16T04:35:04Z | - |
dc.date.available | 2022-03-16T13:41:41Z | - |
dc.date.issued | 2021-11-24 | - |
dc.identifier.citation | BMC Medicine. 2021 Nov 24;19(1):274 | ko_KR |
dc.identifier.issn | 1741-7015 | - |
dc.identifier.uri | https://hdl.handle.net/10371/177015 | - |
dc.description.abstract | Background
Atrial fibrillation (AF) and brain volume loss are prevalent in older individuals. We aimed to assess the causal effect of atrial fibrillation on brain volume phenotypes by Mendelian randomization (MR) analysis. Methods The genetic instrument for AF was constructed from a previous genome-wide association study (GWAS) meta-analysis (15,993 AF patients and 113,719 controls of European ancestry). The outcome summary statistics for head-size-normalized white or gray matter volume measured by magnetic resonance imaging were provided by a previous GWAS of 33,224 white British participants in the UK Biobank. Two-sample MR by the inverse variance–weighted method was performed, supported by pleiotropy-robust MR sensitivity analysis. The causal estimates for the effect of AF on ischemic stroke were also investigated in a dataset that included the findings from the MEGASTROKE study (34,217 stroke patients and 406,111 controls of European ancestry). The direct effects of AF on brain volume phenotypes adjusted for the mediating effect of ischemic stroke were studied by multivariable MR. Results A higher genetic predisposition for AF was significantly associated with lower grey matter volume [beta −0.040, standard error (SE) 0.017, P=0.017], supported by pleiotropy-robust MR sensitivity analysis. Significant causal estimates were identified for the effect of AF on ischemic stroke (beta 0.188, SE 0.026, P=1.03E−12). The total effect of AF on lower brain grey matter volume was attenuated by adjusting for the effect of ischemic stroke (direct effects, beta −0.022, SE 0.033, P=0.528), suggesting that ischemic stroke is a mediator of the identified causal pathway. The causal estimates were nonsignificant for effects on brain white matter volume as an outcome. Conclusions This study identified that genetic predisposition for AF is significantly associated with lower gray matter volume but not white matter volume. The results indicated that the identified total effect of AF on gray matter volume may be mediated by ischemic stroke. | ko_KR |
dc.description.sponsorship | This work was supported by a grant from the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HW20C2066).
The funder played no role in the conduct of the study, and the study was performed independently by the authors. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BMC | ko_KR |
dc.subject | Atrial fibrillation | - |
dc.subject | Brain | - |
dc.subject | Stroke | - |
dc.subject | Mendelian randomization | - |
dc.title | Causal effects of atrial fibrillation on brain white and gray matter volume: a Mendelian randomization study | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 박세훈 | - |
dc.contributor.AlternativeAuthor | 이수진 | - |
dc.contributor.AlternativeAuthor | 김예림 | - |
dc.contributor.AlternativeAuthor | 조세민 | - |
dc.contributor.AlternativeAuthor | 김광수 | - |
dc.contributor.AlternativeAuthor | 김용철 | - |
dc.contributor.AlternativeAuthor | 한승석 | - |
dc.contributor.AlternativeAuthor | 이하정 | - |
dc.contributor.AlternativeAuthor | 이정표 | - |
dc.contributor.AlternativeAuthor | 이소령 | - |
dc.contributor.AlternativeAuthor | 최의근 | - |
dc.contributor.AlternativeAuthor | 주권욱 | - |
dc.contributor.AlternativeAuthor | 임천수 | - |
dc.contributor.AlternativeAuthor | 김연수 | - |
dc.contributor.AlternativeAuthor | 김동기 | - |
dc.identifier.doi | https://doi.org/10.1186/s12916-021-02152-9 | - |
dc.citation.journaltitle | BMC Medicine | ko_KR |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s) | - |
dc.date.updated | 2021-11-28T04:15:40Z | - |
dc.citation.number | 1 | ko_KR |
dc.citation.startpage | 274 | ko_KR |
dc.citation.volume | 19 | ko_KR |
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