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The beneficial effect of palliative resection in metastatic colorectal cancer
DC Field | Value | Language |
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dc.contributor.author | Park, J. H. | - |
dc.contributor.author | Kim, T-Y | - |
dc.contributor.author | Lee, K-H | - |
dc.contributor.author | Han, S-W | - |
dc.contributor.author | Oh, D-Y | - |
dc.contributor.author | Im, S-A | - |
dc.contributor.author | Kang, G. H. | - |
dc.contributor.author | Chie, E. K. | - |
dc.contributor.author | Ha, S. W. | - |
dc.contributor.author | Jeong, S-Y | - |
dc.contributor.author | Park, K. J. | - |
dc.contributor.author | Park, J-G | - |
dc.contributor.author | Kim, TY | - |
dc.date.accessioned | 2022-03-22T09:06:09Z | - |
dc.date.available | 2022-03-22T09:06:09Z | - |
dc.date.created | 2021-02-26 | - |
dc.date.created | 2021-02-26 | - |
dc.date.issued | 2013-04 | - |
dc.identifier.citation | British Journal of Cancer, Vol.108 No.7, pp.1425-1431 | - |
dc.identifier.issn | 0007-0920 | - |
dc.identifier.other | 124176 | - |
dc.identifier.uri | https://hdl.handle.net/10371/177143 | - |
dc.description.abstract | Background: We aimed to determine the role of palliative resection in metastatic colorectal cancer (mCRC) and ascertain which patient populations would benefit most from this treatment. Methods: A total of 1015 patients diagnosed with mCRC at Seoul National University Hospital between 2000 and 2009 were retrospectively studied. Results: Of the 1015 patients, 168 patients with only liver and/or lung metastasis received curative resection. The remaining 847 patients were treated with palliative chemotherapy and/or palliative resection combined with best supportive care. Palliative resection was performed in 527 (62.2%) cases (complete resection with negative margin (R0) in 93, R1/2 in 434). Resected patients had a more prolonged median overall survival (OS) than unresected patients (21.3 vs 14.1 months; P<0.001). In multivariate analysis, R0 resection was found to be associated with a superior OS compared with R1/2 resection (51.3 vs 19.1 months; P<0.001) and no resection (51.3 vs 14.1 months; P<0.001). When we performed propensity score matching, palliative resection was found to be related to prolonged OS (hazard ratio 0.72, 95% confidence interval 0.59-0.89; P = 0.003). Conclusion: Palliative resection without residual disease and chemotherapy confers a longer-term survival outcome than palliative chemotherapy alone in mCRC patient subset. | - |
dc.language | 영어 | - |
dc.publisher | Nature Publishing Group | - |
dc.title | The beneficial effect of palliative resection in metastatic colorectal cancer | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 임석아 | - |
dc.identifier.doi | 10.1038/bjc.2013.94 | - |
dc.citation.journaltitle | British Journal of Cancer | - |
dc.identifier.wosid | 000317730400005 | - |
dc.identifier.scopusid | 2-s2.0-84876496714 | - |
dc.citation.endpage | 1431 | - |
dc.citation.number | 7 | - |
dc.citation.startpage | 1425 | - |
dc.citation.volume | 108 | - |
dc.identifier.sci | 000317730400005 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Oh, D-Y | - |
dc.contributor.affiliatedAuthor | Im, S-A | - |
dc.contributor.affiliatedAuthor | Kang, G. H. | - |
dc.contributor.affiliatedAuthor | Chie, E. K. | - |
dc.contributor.affiliatedAuthor | Park, K. J. | - |
dc.contributor.affiliatedAuthor | Kim, TY | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | CETUXIMAB PLUS IRINOTECAN | - |
dc.subject.keywordPlus | COLON-CANCER | - |
dc.subject.keywordPlus | SURGICAL-TREATMENT | - |
dc.subject.keywordPlus | PULMONARY METASTASES | - |
dc.subject.keywordPlus | FLUOROURACIL | - |
dc.subject.keywordPlus | CHEMOTHERAPY | - |
dc.subject.keywordPlus | OXALIPLATIN | - |
dc.subject.keywordPlus | LEUCOVORIN | - |
dc.subject.keywordPlus | CARCINOMA | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordAuthor | colonic neoplasms | - |
dc.subject.keywordAuthor | resection | - |
dc.subject.keywordAuthor | metastasectomy | - |
dc.subject.keywordAuthor | chemotherapy | - |
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