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Neoadjuvant Chemotherapy Followed by Limited Surgery in a Mouse Model of Head and Neck Cancer
DC Field | Value | Language |
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dc.contributor.author | Lee, Jae Jin | - |
dc.contributor.author | Hah, Jeong-Hun | - |
dc.contributor.author | Im, Seock-Ah | - |
dc.contributor.author | Kim, Si-Young | - |
dc.contributor.author | Sung, Myung-Whun | - |
dc.contributor.author | Kim, Kwang Hyun | - |
dc.contributor.author | Heo, Dae Soeg | - |
dc.date.accessioned | 2022-03-22T09:06:31Z | - |
dc.date.available | 2022-03-22T09:06:31Z | - |
dc.date.created | 2021-11-23 | - |
dc.date.created | 2021-11-23 | - |
dc.date.issued | 2009-01 | - |
dc.identifier.citation | Anticancer Research, Vol.29 No.1, pp.255-259 | - |
dc.identifier.issn | 0250-7005 | - |
dc.identifier.other | 148342 | - |
dc.identifier.uri | https://hdl.handle.net/10371/177150 | - |
dc.description.abstract | Background: This study evaluated the effect of limited surgery following neoadjuvant chemotherapy compared to radical surgery in SCC VII (squamous cell cancer) tumor-bearing syngeneic C3H/HeJ mice. Materials and Methods: Mice showing a tumor response to cisplatin and 5-fluorouracil therapy were divided into three groups: radical surgery, with a 5 nun margin from the original tumor, group (A); limited surgery of 5 mm margin from the residual tumor, group (B); and very limited surgery with no margin from the residual tumor, group (C). The number of mice was 13 (group A), 12 (group B) and 12 (group C). Results: No recurrence developed except in one mouse in group C. Three mice died in group A, one in group B and one in group C from perioperative complications. By intent-to-treat analysis, the survival was not significantly different among the three groups (p=0.64), or between group A and B (p=0.33). Conclusion: The outcome of limited surgery was comparable to radical surgery after neoadjuvant chemotherapy in the mouse model of head and neck cancer. | - |
dc.language | 영어 | - |
dc.publisher | International Institute of Anticancer Research | - |
dc.title | Neoadjuvant Chemotherapy Followed by Limited Surgery in a Mouse Model of Head and Neck Cancer | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 임석아 | - |
dc.citation.journaltitle | Anticancer Research | - |
dc.identifier.wosid | 000263731100032 | - |
dc.identifier.scopusid | 2-s2.0-61449167178 | - |
dc.citation.endpage | 259 | - |
dc.citation.number | 1 | - |
dc.citation.startpage | 255 | - |
dc.citation.volume | 29 | - |
dc.identifier.sci | 000263731100032 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Im, Seock-Ah | - |
dc.contributor.affiliatedAuthor | Sung, Myung-Whun | - |
dc.contributor.affiliatedAuthor | Kim, Kwang Hyun | - |
dc.contributor.affiliatedAuthor | Heo, Dae Soeg | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | SQUAMOUS-CELL CARCINOMA | - |
dc.subject.keywordPlus | QUALITY-OF-LIFE | - |
dc.subject.keywordPlus | INDUCTION CHEMOTHERAPY | - |
dc.subject.keywordPlus | OROPHARYNGEAL CANCER | - |
dc.subject.keywordPlus | POSITIVE MARGINS | - |
dc.subject.keywordPlus | SURGICAL MARGINS | - |
dc.subject.keywordPlus | LOCAL RECURRENCE | - |
dc.subject.keywordPlus | TONGUE | - |
dc.subject.keywordPlus | PERSPECTIVE | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordAuthor | Head and neck cancer | - |
dc.subject.keywordAuthor | neoadjuvant chemotherapy | - |
dc.subject.keywordAuthor | limited surgery | - |
dc.subject.keywordAuthor | prognosis | - |
dc.subject.keywordAuthor | radical surgery | - |
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