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High-dose versus low-dose cyclophosphamide in combination with G-CSF for peripheral blood progenitor cell mobilization
DC Field | Value | Language |
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dc.contributor.author | Ahn, Jin Seok | - |
dc.contributor.author | Park, Seonyang | - |
dc.contributor.author | Im, Seock-Ah | - |
dc.contributor.author | Yoon, Sung-Soo | - |
dc.contributor.author | Lee, Jong-Seok | - |
dc.contributor.author | Kim, Byoung Kook | - |
dc.contributor.author | Bang, Soo-Mee | - |
dc.contributor.author | Cho, Eun Kyung | - |
dc.contributor.author | Lee, Jae Hoon | - |
dc.contributor.author | Jung, Chul Won | - |
dc.contributor.author | Kim, Hugh Chul | - |
dc.contributor.author | Seong, Chu Myung | - |
dc.contributor.author | Lee, Moon Hee | - |
dc.contributor.author | Kim, Chul Soo | - |
dc.contributor.author | Lee, Keun Seok | - |
dc.contributor.author | Lee, Jung Ae | - |
dc.contributor.author | Ahn, Myung-Ju | - |
dc.date.accessioned | 2022-03-22T09:06:59Z | - |
dc.date.available | 2022-03-22T09:06:59Z | - |
dc.date.created | 2021-11-23 | - |
dc.date.created | 2021-11-23 | - |
dc.date.issued | 2005-09 | - |
dc.identifier.citation | The Korean Journal of Internal Medicine, Vol.20 No.3, pp.224-231 | - |
dc.identifier.issn | 1226-3303 | - |
dc.identifier.other | 148315 | - |
dc.identifier.uri | https://hdl.handle.net/10371/177157 | - |
dc.description.abstract | Background: To compare the mobilizing effects and toxicities of two different doses of cyclophosphamide (CY) plus lenograstim (glycosylated G-CSF), we performed a prospective randomized study by enrolling patients suffering with either high-risk Non-Hodgkin's lymphoma (NHL) or breast cancer undergoing ablative chemotherapy. Methods: The NHL patients received 4 cycles of CHOP and the breast cancer patients received 2-3 cycles of FAC (FEC) adjuvant chemotherapy. Then, the patients were randomly allocated to receive CY 4 g/m2 (arm A) or 1.5 g/m2 (arm B) in combination with lenograstim. Large volume leukapheresis was carried out and it was continued daily until the target cell dose of 2 × 106 CD34+ cell/kg was reached. Results: Twenty-seven patients were enrolled in the study. The median number of leukaphereis sessions actually performed was 2.5 sessions in arm A and 3 sessions in arm B. The target cell dose was obtained with the median number of one leukapheresis session in both arms of the study (p=0.09). The collected number of CD34+ cells in the leukapheresis products was higher in arm A than arm B (22.4 vs. 9.9 × 106/kg, respectively, p=0.05). Grade III or IV leukopenia was present in 14/15 patients (94%) in arm A and in 1/12 patients (8%) in arm B (p<0.0001). Grade III or IV thrombocytopenia was present in 8/15 patients (54%) in arm A, but this was not present in any patients of arm B (p=0.0004). Neutropenic fever occurred in 6/15 patients (40%) in arm A, and in 1/12 patients (8%) in arm B (p=0.09). The hematological recovery of the leukocytes and platelets after transplantation was not statistically different between the two doses. Conclusion: Low-dose CY plus lenograstim is a safe and effective mobilizing regimen. | - |
dc.language | 영어 | - |
dc.publisher | 대한내과학회 | - |
dc.title | High-dose versus low-dose cyclophosphamide in combination with G-CSF for peripheral blood progenitor cell mobilization | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 임석아 | - |
dc.identifier.doi | 10.3904/kjim.2005.20.3.224 | - |
dc.citation.journaltitle | The Korean Journal of Internal Medicine | - |
dc.identifier.scopusid | 2-s2.0-28444440311 | - |
dc.citation.endpage | 231 | - |
dc.citation.number | 3 | - |
dc.citation.startpage | 224 | - |
dc.citation.volume | 20 | - |
dc.identifier.kciid | ART001030049 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Park, Seonyang | - |
dc.contributor.affiliatedAuthor | Im, Seock-Ah | - |
dc.contributor.affiliatedAuthor | Yoon, Sung-Soo | - |
dc.contributor.affiliatedAuthor | Lee, Jong-Seok | - |
dc.contributor.affiliatedAuthor | Kim, Byoung Kook | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordAuthor | Cyclophosphamide | - |
dc.subject.keywordAuthor | Granulocyte colony-stimulating factor | - |
dc.subject.keywordAuthor | Hematopoietic stem cell mobilization | - |
dc.subject.keywordAuthor | Progenitor cell | - |
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