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Small node-negative (T1b-cN0) invasive hormone receptor-positive breast cancers: Is there a subpopulation that might have benefit from adjuvant chemotherapy?
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Yeon Hee | - |
dc.contributor.author | Im, Seock-Ah | - |
dc.contributor.author | Cho, Eun Yoon | - |
dc.contributor.author | Choi, Yoon-La | - |
dc.contributor.author | Lee, Jeong Eon | - |
dc.contributor.author | Nam, Seok Jin | - |
dc.contributor.author | Yang, Jung Hyun | - |
dc.contributor.author | Ahn, Jin Seok | - |
dc.contributor.author | Im, Young-Hyuck | - |
dc.date.accessioned | 2022-03-22T09:09:51Z | - |
dc.date.available | 2022-03-22T09:09:51Z | - |
dc.date.created | 2021-02-24 | - |
dc.date.created | 2021-02-24 | - |
dc.date.created | 2021-02-24 | - |
dc.date.created | 2021-02-24 | - |
dc.date.created | 2021-02-24 | - |
dc.date.created | 2021-02-24 | - |
dc.date.issued | 2012-05 | - |
dc.identifier.citation | Breast Cancer Research and Treatment, Vol.133 No.1, pp.247-255 | - |
dc.identifier.issn | 0167-6806 | - |
dc.identifier.other | 123863 | - |
dc.identifier.uri | https://hdl.handle.net/10371/177184 | - |
dc.description.abstract | The aims of the study were to identify a subpopulation more likely to be at greater risk of recurrence in small T1b-c node-negative hormone receptor (HR)-positive breast cancer, and which would benefit from adjuvant chemotherapy. Clinico-pathologic characteristics and clinical outcomes of 538 postoperative HR-positive T1b-cN0 breast cancer patients were retrospectively analyzed. High Ki67 index and a young age (< 35 years) were identified as independent risk factors for relapse (p < 0.0001 and 0.015, respectively). A nomogram based on Cox-regression model showed an area under the curve (AUC) of 0.73 in the training set. The validation set showed a good discrimination with an AUC of 0.65. In patients with high nomogram scores (a parts per thousand yen100, n = 24, 4.5%) who had high Ki67 index with more than 75%, or young age (< 35 years) and a Ki67 index > 50%, the relapse-free survival curve of patients who had received anthracycline-containing adjuvant chemotherapy showed a better outcome than those who had not (p = 0.029). Ki67 index and age are valuable surrogate markers to predict recurrence and as indicators of tumors that could benefit from adjuvant chemotherapy in small T1b-c node-negative HR-positive breast cancer. | - |
dc.language | 영어 | - |
dc.publisher | Kluwer Academic Publishers | - |
dc.title | Small node-negative (T1b-cN0) invasive hormone receptor-positive breast cancers: Is there a subpopulation that might have benefit from adjuvant chemotherapy? | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 임석아 | - |
dc.identifier.doi | 10.1007/s10549-012-1956-1 | - |
dc.citation.journaltitle | Breast Cancer Research and Treatment | - |
dc.identifier.wosid | 000303509200023 | - |
dc.identifier.scopusid | 2-s2.0-84860332052 | - |
dc.citation.endpage | 255 | - |
dc.citation.number | 1 | - |
dc.citation.startpage | 247 | - |
dc.citation.volume | 133 | - |
dc.identifier.sci | 000303509200023 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Im, Seock-Ah | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | PATHOLOGICAL COMPLETE RESPONSE | - |
dc.subject.keywordPlus | GENE-EXPRESSION PATTERNS | - |
dc.subject.keywordPlus | ESTROGEN-RECEPTOR | - |
dc.subject.keywordPlus | REPORTING RECOMMENDATIONS | - |
dc.subject.keywordPlus | PREOPERATIVE CHEMOTHERAPY | - |
dc.subject.keywordPlus | POSTMENOPAUSAL WOMEN | - |
dc.subject.keywordPlus | TAMOXIFEN | - |
dc.subject.keywordPlus | ANASTROZOLE | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | SUBTYPES | - |
dc.subject.keywordAuthor | Hormone receptor-positive breast cancer | - |
dc.subject.keywordAuthor | < | - |
dc.subject.keywordAuthor | = 1 cm invasive breast cancer | - |
dc.subject.keywordAuthor | Adjuvant treatment | - |
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