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Lymph Node Ratio after Neoadjuvant Chemotherapy for Stage II/III Breast Cancer: Prognostic Value Measured with Gini's Mean Difference of Restricted Mean Survival Times
DC Field | Value | Language |
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dc.contributor.author | Keam, Bhumsuk | - |
dc.contributor.author | Gorobets, Olena | - |
dc.contributor.author | Vinh-Hung, Vincent | - |
dc.contributor.author | Im, Seock-Ah | - |
dc.date.accessioned | 2022-03-22T09:10:32Z | - |
dc.date.available | 2022-03-22T09:10:32Z | - |
dc.date.created | 2021-11-08 | - |
dc.date.created | 2021-11-08 | - |
dc.date.created | 2021-11-08 | - |
dc.date.issued | 2021-10 | - |
dc.identifier.citation | Cancer Informatics, Vol.20, pp.1-9 | - |
dc.identifier.issn | 1176-9351 | - |
dc.identifier.other | 147215 | - |
dc.identifier.uri | https://hdl.handle.net/10371/177198 | - |
dc.description.abstract | Restricted mean survival time (RMST), recommended for reporting survival, lacks a tool to evaluate multilevel factors. The potential of the Gini's mean difference of RMSTs (Delta) is explored in a comparison of a lymph node ratio-based classification (LNRc) versus a number-based classification (ypN) applied to stage II/III breast cancer patients who received neoadjuvant chemotherapy and underwent axillary dissection. Number of positive nodes (npos) classified patients into ypN0, npos = 0, ypN1, npos = [1,3], ypN2, npos = [4,9], and ypN3, npos > 10. Ratio npos/(number of nodes examined) of 0, (0,0.20], (0.20,0.65], and >0.65, classified patients into Lnr0 to Lnr3, respectively. Unadjusted and Cox-adjusted RMSTs were computed for the ypN and LNRc's. At a follow-up time horizon of 72 months for 114 node-negative and 254 node-positive patients, unadjusted ypN0-ypN3 RMSTs were 62.4-41.4 months, Delta = 11.9 months (95%CI: 7.4-16.9), and Lnr0-Lnr3 62.4 to 36.3 months, Delta = 14.0 months (95%CI: 10.1-18.1). Cox models' ypN1-ypN3 hazard ratios were 1.81-3.30, and Lnr1-Lnr3 1.52-4.39. Delta from Cox-fitted survival were ypN 8.1 months (95%CI: 5.9-10.5), LNRc 10.5 months (95%CI: 8.4-12.8). In conclusion, Gini's mean difference is applicable to well established data in keeping with the literature on LNRc. It provides an alternative view on the improvement gained with a lymph node ratio-classification over using a number-classification. | - |
dc.language | 영어 | - |
dc.publisher | Libertas Academica | - |
dc.title | Lymph Node Ratio after Neoadjuvant Chemotherapy for Stage II/III Breast Cancer: Prognostic Value Measured with Gini's Mean Difference of Restricted Mean Survival Times | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 임석아 | - |
dc.identifier.doi | 10.1177/11769351211051675 | - |
dc.citation.journaltitle | Cancer Informatics | - |
dc.identifier.wosid | 000708898100001 | - |
dc.identifier.scopusid | 2-s2.0-85117132987 | - |
dc.citation.endpage | 9 | - |
dc.citation.startpage | 1 | - |
dc.citation.volume | 20 | - |
dc.identifier.sci | 000708898100001 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Im, Seock-Ah | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | REGRESSION | - |
dc.subject.keywordPlus | SIMULATION | - |
dc.subject.keywordPlus | TRIALS | - |
dc.subject.keywordPlus | MODELS | - |
dc.subject.keywordAuthor | Dispersion | - |
dc.subject.keywordAuthor | information value | - |
dc.subject.keywordAuthor | predictive models | - |
dc.subject.keywordAuthor | regression analysis | - |
dc.subject.keywordAuthor | separation | - |
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