Publications
Detailed Information
Prognostic and predictive values of EGFR overexpression and EGFR copy number alteration in HER2-positive breast cancer
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, H. J. | - |
dc.contributor.author | Seo, A. N. | - |
dc.contributor.author | Kim, E. J. | - |
dc.contributor.author | Jang, M. H. | - |
dc.contributor.author | Kim, Y. J. | - |
dc.contributor.author | Kim, J. H. | - |
dc.contributor.author | Kim, S. -W. | - |
dc.contributor.author | Ryu, H. S. | - |
dc.contributor.author | Park, I. A. | - |
dc.contributor.author | Im, S. -A. | - |
dc.contributor.author | Gong, G. | - |
dc.contributor.author | Jung, K. H. | - |
dc.contributor.author | Kim, H. J. | - |
dc.contributor.author | Park, S. Y. | - |
dc.date.accessioned | 2022-03-22T09:22:11Z | - |
dc.date.available | 2022-03-22T09:22:11Z | - |
dc.date.created | 2018-10-01 | - |
dc.date.created | 2018-10-01 | - |
dc.date.issued | 2015-01 | - |
dc.identifier.citation | British Journal of Cancer, Vol.112 No.1, pp.103-111 | - |
dc.identifier.issn | 0007-0920 | - |
dc.identifier.other | 57147 | - |
dc.identifier.uri | https://hdl.handle.net/10371/177268 | - |
dc.description.abstract | Background: Epidermal growth factor receptor (EGFR) is overexpressed in a subset of human epidermal growth factor receptor 2 (HER2)-positive breast cancers, and coexpression of HER2 and EGFR has been reported to be associated with poor clinical outcome. Moreover, interaction between HER2 and EGFR has been suggested to be a possible basis for trastuzumab resistance. Methods: We analysed the clinical significance of EGFR overexpression and EGFR gene copy number alterations in 242 HER2-positive primary breast cancers. In addition, we examined the correlations between EGFR overexpression, trastuzumab response and clinical outcome in 447 primary, and 112 metastatic HER2-positive breast cancer patients treated by trastuzumab. Results: Of the 242 primary cases, the level of EGFR overexpression was 2+ in 12.7% and 3+ in 11.8%. High EGFR gene copy number was detected in 10.3%. Epidermal growth factor receptor overexpression was associated with hormone receptor negativity and high Ki-67 proliferation index. In survival analyses, EGFR overexpression, but not high EGFR copy number, was associated with poor disease-free survival in all patients, and in the subgroup not receiving adjuvant trastuzumab. In 447 HER2-positive primary breast cancer patients treated with adjuvant trastuzumab, EGFR overexpression was also an independent poor prognostic factor. However, EGFR overexpression was not associated with trastuzumab response, progression-free survival or overall survival in the metastatic setting. Conclusions: Epidermal growth factor receptor overexpression, but not high EGFR copy number, is a poor prognostic factor in HER2-positive primary breast cancer. Epidermal growth factor receptor overexpression is a predictive factor for trastuzumab response in HER2-positive primary breast cancer, but not in metastatic breast cancer. | - |
dc.language | 영어 | - |
dc.publisher | Nature Publishing Group | - |
dc.title | Prognostic and predictive values of EGFR overexpression and EGFR copy number alteration in HER2-positive breast cancer | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 임석아 | - |
dc.identifier.doi | 10.1038/bjc.2014.556 | - |
dc.citation.journaltitle | British Journal of Cancer | - |
dc.identifier.wosid | 000348280900016 | - |
dc.identifier.scopusid | 2-s2.0-84920686176 | - |
dc.citation.endpage | 111 | - |
dc.citation.number | 1 | - |
dc.citation.startpage | 103 | - |
dc.citation.volume | 112 | - |
dc.identifier.sci | 000348280900016 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Kim, J. H. | - |
dc.contributor.affiliatedAuthor | Park, I. A. | - |
dc.contributor.affiliatedAuthor | Im, S. -A. | - |
dc.contributor.affiliatedAuthor | Park, S. Y. | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | GROWTH-FACTOR RECEPTOR | - |
dc.subject.keywordPlus | GENE AMPLIFICATION | - |
dc.subject.keywordPlus | PROTEIN EXPRESSION | - |
dc.subject.keywordPlus | TRASTUZUMAB | - |
dc.subject.keywordPlus | HER2 | - |
dc.subject.keywordPlus | CARCINOMAS | - |
dc.subject.keywordPlus | GEFITINIB | - |
dc.subject.keywordPlus | SENSITIVITY | - |
dc.subject.keywordPlus | RESISTANCE | - |
dc.subject.keywordPlus | HERCEPTIN | - |
dc.subject.keywordAuthor | breast carcinoma | - |
dc.subject.keywordAuthor | gene amplification | - |
dc.subject.keywordAuthor | EGFR | - |
dc.subject.keywordAuthor | HER2 | - |
dc.subject.keywordAuthor | trastuzumab | - |
dc.subject.keywordAuthor | immunohistochemistry | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.