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An NMR metabolomics approach for the diagnosis of leptomeningeal carcinomatosis in lung adenocarcinoma cancer patients
DC Field | Value | Language |
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dc.contributor.author | An, Yong Jin | - |
dc.contributor.author | Cho, Hye Rim | - |
dc.contributor.author | Kim, Tae Min | - |
dc.contributor.author | Keam, Bhumsuk | - |
dc.contributor.author | Kim, Jin Wook | - |
dc.contributor.author | Wen, He | - |
dc.contributor.author | Park, Chul-Kee | - |
dc.contributor.author | Lee, Se-Hoon | - |
dc.contributor.author | Im, Seock-Ah | - |
dc.contributor.author | Kim, Jeong Eun | - |
dc.contributor.author | Choi, Seung Hong | - |
dc.contributor.author | Park, Sunghyouk | - |
dc.date.accessioned | 2022-03-22T09:22:20Z | - |
dc.date.available | 2022-03-22T09:22:20Z | - |
dc.date.created | 2017-11-15 | - |
dc.date.created | 2017-11-15 | - |
dc.date.created | 2017-11-15 | - |
dc.date.created | 2017-11-15 | - |
dc.date.issued | 2015-01 | - |
dc.identifier.citation | International Journal of Cancer, Vol.136 No.1, pp.162-171 | - |
dc.identifier.issn | 0020-7136 | - |
dc.identifier.other | 1120 | - |
dc.identifier.uri | https://hdl.handle.net/10371/177269 | - |
dc.description.abstract | Leptomeningeal carcinomatosis (LC) is a metastatic cancer invading the central nervous system (CNS). We previously reported a metabolomic diagnostic approach as tested on an animal model and compared with current modalities. Here, we provide a proof of concept by applying it to human LC originating from lung cancer, the most common cause of CNS metastasis. Cerebrospinal fluid from LC (n = 26) and normal groups (n = 41) were obtained, and the diagnosis was established with clinical signs, cytology, MRI and biochemical tests. The cytology on the CSF, the current gold standard, exhibited 69% sensitivity (similar to 100% specificity) from the first round of CSF tapping. In comparison, the nuclear magnetic resonance spectra on the CSF showed a clear difference in the metabolic profile between the LC and normal groups. Multivariate analysis and cross-validation yielded the diagnostic sensitivity of 92%, the specificity of 96% and the area under the curve (AUC) of 0.991. Further spectral and statistical analysis identified myo-inositol (p < 5 x 10(-14)), creatine (p < 7 x 10(-8)), lactate (p < 9 x 10(-4)), alanine (p < 7.9 x 10(-3)) and citrate (p < 3 x 10(-4)) as the most contributory metabolites, whose combination exhibited an receiver-operating characteristic diagnostic AUC of 0.996. In addition, the metabolic profile could be correlated with the grading of radiological leptomeningeal enhancement (R-2 = 0.3881 and p = 6.66 x 10(-4)), suggesting its potential utility in grading LC. Overall, we propose that the metabolomic approach might augment current diagnostic modalities for LC, the accurate diagnosis of which remains a challenge. | - |
dc.language | 영어 | - |
dc.publisher | John Wiley & Sons Inc. | - |
dc.title | An NMR metabolomics approach for the diagnosis of leptomeningeal carcinomatosis in lung adenocarcinoma cancer patients | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 임석아 | - |
dc.identifier.doi | 10.1002/ijc.28949 | - |
dc.citation.journaltitle | International Journal of Cancer | - |
dc.identifier.wosid | 000344011400017 | - |
dc.identifier.scopusid | 2-s2.0-84921692242 | - |
dc.citation.endpage | 171 | - |
dc.citation.number | 1 | - |
dc.citation.startpage | 162 | - |
dc.citation.volume | 136 | - |
dc.identifier.sci | 000344011400017 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Kim, Jin Wook | - |
dc.contributor.affiliatedAuthor | Park, Chul-Kee | - |
dc.contributor.affiliatedAuthor | Im, Seock-Ah | - |
dc.contributor.affiliatedAuthor | Kim, Jeong Eun | - |
dc.contributor.affiliatedAuthor | Choi, Seung Hong | - |
dc.contributor.affiliatedAuthor | Park, Sunghyouk | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | MAGNETIC-RESONANCE-SPECTROSCOPY | - |
dc.subject.keywordPlus | CEREBROSPINAL-FLUID CYTOLOGY | - |
dc.subject.keywordPlus | BRAIN METASTASES | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | LACTATE | - |
dc.subject.keywordPlus | CHEMOTHERAPY | - |
dc.subject.keywordPlus | PROFILES | - |
dc.subject.keywordPlus | HYALURONAN | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | CISPLATIN | - |
dc.subject.keywordAuthor | metabolomics | - |
dc.subject.keywordAuthor | leptomeningeal carcinomatosis | - |
dc.subject.keywordAuthor | CSF | - |
dc.subject.keywordAuthor | diagnosis | - |
dc.subject.keywordAuthor | metastasis | - |
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