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Phase II study of neoadjuvant imatinib in large gastrointestinal stromal tumours of the stomach
DC Field | Value | Language |
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dc.contributor.author | Kurokawa, Yukinori | - |
dc.contributor.author | Yang, Han-Kwang | - |
dc.contributor.author | Cho, Haruhiko | - |
dc.contributor.author | Ryu, Min-Hee | - |
dc.contributor.author | Masuzawa, Toru | - |
dc.contributor.author | Park, Sook Ryun | - |
dc.contributor.author | Matsumoto, Sohei | - |
dc.contributor.author | Lee, Hyuk-Joon | - |
dc.contributor.author | Honda, Hiroshi | - |
dc.contributor.author | Kwon, Oh Kyoung | - |
dc.contributor.author | Ishikawa, Takashi | - |
dc.contributor.author | Lee, Kyung Hee | - |
dc.contributor.author | Nabeshima, Kazuhito | - |
dc.contributor.author | Kong, Seong-Ho | - |
dc.contributor.author | Shimokawa, Toshio | - |
dc.contributor.author | Yook, Jeong-Hwan | - |
dc.contributor.author | Doki, Yuichiro | - |
dc.contributor.author | Im, Seock-Ah | - |
dc.contributor.author | Hirota, Seiichi | - |
dc.contributor.author | Hahn, Seokyung | - |
dc.contributor.author | Nishida, Toshirou | - |
dc.contributor.author | Kang, Yoon-Koo | - |
dc.date.accessioned | 2022-03-22T09:23:37Z | - |
dc.date.available | 2022-03-22T09:23:37Z | - |
dc.date.created | 2018-09-07 | - |
dc.date.created | 2018-09-07 | - |
dc.date.issued | 2017-06 | - |
dc.identifier.citation | British Journal of Cancer, Vol.117 No.1, pp.25-32 | - |
dc.identifier.issn | 0007-0920 | - |
dc.identifier.other | 51784 | - |
dc.identifier.uri | https://hdl.handle.net/10371/177297 | - |
dc.description.abstract | Background: Gastrointestinal stromal tumours (GISTs) with high-risk features have poor prognosis even if adjuvant treatment is given. Neoadjuvant imatinib may increase the cure rate by shrinking large GISTs and preserve organ function. Methods: We conducted an Asian multinational phase II study for patients with gastric GISTs >= 10 cm. Patients received neoadjuvant imatinib (400 mg/day) for 6-9 months. The primary end point was R0 resection rate. Results: A total of 56 patients were enroled in this study. In the full analysis set of 53 patients, neoadjuvant imatinib for >= 6 months was completed in 46 patients. Grade 3-4 neutropenia and rash occurred in 8% and 9%, respectively, but there were no treatment-related deaths. The response rate by RECIST was 62% (95% CI, 48-75%). The R0 resection rate was 91% (48/53) (95% CI, 79-97%). Preservation of at least half of the stomach was achieved in 42 of 48 patients with R0 resection. At the median follow-up time of 32 months, 2-year overall and progression-free survival rates were 98% and 89%, respectively. Conclusions: Neoadjuvant imatinib treatment for 6-9 months is a promising treatment for large gastric GISTs, allowing a high R0 resection rate with acceptable toxicity. | - |
dc.language | 영어 | - |
dc.publisher | Nature Publishing Group | - |
dc.title | Phase II study of neoadjuvant imatinib in large gastrointestinal stromal tumours of the stomach | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 임석아 | - |
dc.identifier.doi | 10.1038/bjc.2017.144 | - |
dc.citation.journaltitle | British Journal of Cancer | - |
dc.identifier.wosid | 000404111300004 | - |
dc.identifier.scopusid | 2-s2.0-85021443124 | - |
dc.citation.endpage | 32 | - |
dc.citation.number | 1 | - |
dc.citation.startpage | 25 | - |
dc.citation.volume | 117 | - |
dc.identifier.sci | 000404111300004 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Yang, Han-Kwang | - |
dc.contributor.affiliatedAuthor | Lee, Hyuk-Joon | - |
dc.contributor.affiliatedAuthor | Im, Seock-Ah | - |
dc.contributor.affiliatedAuthor | Hahn, Seokyung | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | OF-FUNCTION MUTATIONS | - |
dc.subject.keywordPlus | ADJUVANT IMATINIB | - |
dc.subject.keywordPlus | RANDOMIZED-TRIAL | - |
dc.subject.keywordPlus | MESYLATE | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | RECURRENCE | - |
dc.subject.keywordPlus | PROGNOSIS | - |
dc.subject.keywordPlus | PATHOLOGY | - |
dc.subject.keywordPlus | RESECTION | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordAuthor | GIST | - |
dc.subject.keywordAuthor | imatinib | - |
dc.subject.keywordAuthor | neoadjuvant | - |
dc.subject.keywordAuthor | preoperative | - |
dc.subject.keywordAuthor | stomach | - |
dc.subject.keywordAuthor | gastric | - |
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