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Two-year adjuvant imatinib mesylate after complete resection of localized, high-risk GIST with KIT exon 11 mutation
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kang, Yoon-Koo | - |
dc.contributor.author | Kang, Byung Woog | - |
dc.contributor.author | Im, Seock-Ah | - |
dc.contributor.author | Lee, Jae-Lyun | - |
dc.contributor.author | Park, Sook Ryun | - |
dc.contributor.author | Kang, Won Ki | - |
dc.contributor.author | Chang, Heung Moon | - |
dc.contributor.author | Kim, Tae Won | - |
dc.contributor.author | Oh, Do-Youn | - |
dc.contributor.author | Jung, Kyung Hae | - |
dc.contributor.author | Ryu, Min-Hee | - |
dc.date.accessioned | 2022-03-22T09:25:00Z | - |
dc.date.available | 2022-03-22T09:25:00Z | - |
dc.date.created | 2020-07-15 | - |
dc.date.created | 2020-07-15 | - |
dc.date.created | 2020-07-15 | - |
dc.date.created | 2020-07-15 | - |
dc.date.issued | 2013-01 | - |
dc.identifier.citation | Cancer Chemotherapy and Pharmacology, Vol.71 No.1, pp.43-51 | - |
dc.identifier.issn | 0344-5704 | - |
dc.identifier.other | 106635 | - |
dc.identifier.uri | https://hdl.handle.net/10371/177345 | - |
dc.description.abstract | To evaluate the efficacy and safety of 2-year adjuvant imatinib for patients at high risk of recurrence after complete resection of localized gastrointestinal stromal tumor with KIT exon 11 mutation. Imatinib 400 mg/d was administered until disease recurrence, intolerable toxicities, or for 2 years. The primary end point was recurrence-free survival. Patients (n = 47) from 4 centers in Korea were enrolled. Treatment was well tolerated. Grade 3-4 toxicities included neutropenia (27.7 %), skin rash (8.5 %), anorexia (4.3 %), and constipation (2.1 %). At a median follow-up of 56.7 months, 19 patients had recurrences. Median recurrence-free survival was 58.9 months, which was significantly longer than 22.7 months from historical data of 27 patients in the pre-imatinib era (P < 0.0001). Imatinib was rechallenged for 15 patients with recurrence after completion of adjuvant imatinib. Thirteen patients had partial response, and two had stable disease. There was only one death so far. Postoperative adjuvant imatinib for 2 years was safe and could prolong the recurrence-free survival in patients with a high risk of recurrence after complete resection of localized KIT exon 11 mutated gastrointestinal stromal tumor. Reintroduction of imatinib after recurrence appears to be effective if the recurrence develops after completion of adjuvant imatinib. | - |
dc.language | 영어 | - |
dc.publisher | Springer Verlag | - |
dc.title | Two-year adjuvant imatinib mesylate after complete resection of localized, high-risk GIST with KIT exon 11 mutation | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 임석아 | - |
dc.identifier.doi | 10.1007/s00280-012-1970-3 | - |
dc.citation.journaltitle | Cancer Chemotherapy and Pharmacology | - |
dc.identifier.wosid | 000313004900006 | - |
dc.identifier.scopusid | 2-s2.0-84872338974 | - |
dc.citation.endpage | 51 | - |
dc.citation.number | 1 | - |
dc.citation.startpage | 43 | - |
dc.citation.volume | 71 | - |
dc.identifier.sci | 000313004900006 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Im, Seock-Ah | - |
dc.contributor.affiliatedAuthor | Oh, Do-Youn | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | GASTROINTESTINAL STROMAL TUMORS | - |
dc.subject.keywordPlus | C-KIT | - |
dc.subject.keywordPlus | TYROSINE KINASE | - |
dc.subject.keywordPlus | PROGNOSIS | - |
dc.subject.keywordPlus | INHIBITOR | - |
dc.subject.keywordPlus | DELETIONS | - |
dc.subject.keywordAuthor | Gastrointestinal stromal tumor | - |
dc.subject.keywordAuthor | Adjuvant imatinib mesylate | - |
dc.subject.keywordAuthor | KIT exon 11 mutation | - |
dc.subject.keywordAuthor | High risk | - |
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