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Low Adherence to Upfront and Extended Adjuvant Letrozole Therapy among Early Breast Cancer Patients in a Clinical Practice Setting
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Hye-Suk | - |
dc.contributor.author | Lee, Ju-Yeun | - |
dc.contributor.author | Ah, Young-Mi | - |
dc.contributor.author | Kim, Hyang-Sook | - |
dc.contributor.author | Im, Seock-Ah | - |
dc.contributor.author | Noh, Dong-Young | - |
dc.contributor.author | Lee, Byung Koo | - |
dc.date.accessioned | 2022-03-22T09:25:02Z | - |
dc.date.available | 2022-03-22T09:25:02Z | - |
dc.date.created | 2020-07-14 | - |
dc.date.created | 2020-07-14 | - |
dc.date.created | 2020-07-14 | - |
dc.date.created | 2020-07-14 | - |
dc.date.created | 2020-07-14 | - |
dc.date.created | 2020-07-14 | - |
dc.date.created | 2020-07-14 | - |
dc.date.issued | 2014-07 | - |
dc.identifier.citation | Oncology, Vol.86 No.5-6, pp.340-349 | - |
dc.identifier.issn | 0030-2414 | - |
dc.identifier.other | 106336 | - |
dc.identifier.uri | https://hdl.handle.net/10371/177346 | - |
dc.description.abstract | Objective:The aim of this study was to investigate the prevalence and causes of early discontinuation and non-adherence to upfront and extended adjuvant letrozole therapy in breast cancer patients. Methods: Adherence was assessed using medical charts and longitudinal pharmacy records of 609 patients who initiated adjuvant letrozole between January 2002 and April 2011. A Cox proportional hazards regression model was adopted to identify potential predictors of non-adherence. Results: The overall adherence rate after 1 year of therapy was 79.5%, with cumulative rates declining to 63.7% after 3 years and 57.1% after 5 years. A significantly lower rate of adherence in the extended adjuvant group was observed compared with the upfront adjuvant group (49.0 vs. 72.5%, p < 0.001). Adverse events (50.4%) were the major cause of early discontinuation, with musculoskeletal pain (73.2%) being the single most cited reason. Additional factors correlating with non-adherence in the upfront adjuvant group included a delay in initiation of adjuvant hormone therapy, breast-conserving surgery, calcium supplements, bisphosphonate therapy and concomitant medication for co-morbidity. Conclusions: We observed that approximately 57% of patients fully adhered to letrozole therapy over a 5-year treatment period, and that the adherence to extended letrozole was meaningfully lower than the upfront adjuvant letrozole in a clinical practice setting. (C) 2014 S. Karger AG, Basel | - |
dc.language | 영어 | - |
dc.publisher | S. Karger AG | - |
dc.title | Low Adherence to Upfront and Extended Adjuvant Letrozole Therapy among Early Breast Cancer Patients in a Clinical Practice Setting | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 임석아 | - |
dc.identifier.doi | 10.1159/000360702 | - |
dc.citation.journaltitle | Oncology | - |
dc.identifier.wosid | 000338975100012 | - |
dc.identifier.scopusid | 2-s2.0-84902039261 | - |
dc.citation.endpage | 349 | - |
dc.citation.number | 5-6 | - |
dc.citation.startpage | 340 | - |
dc.citation.volume | 86 | - |
dc.identifier.sci | 000338975100012 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Im, Seock-Ah | - |
dc.contributor.affiliatedAuthor | Noh, Dong-Young | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | ENDOCRINE THERAPY | - |
dc.subject.keywordPlus | AROMATASE INHIBITORS | - |
dc.subject.keywordPlus | HORMONAL-THERAPY | - |
dc.subject.keywordPlus | POSTMENOPAUSAL WOMEN | - |
dc.subject.keywordPlus | TAMOXIFEN | - |
dc.subject.keywordPlus | TRIAL | - |
dc.subject.keywordPlus | NONADHERENCE | - |
dc.subject.keywordPlus | ANASTROZOLE | - |
dc.subject.keywordPlus | COHORT | - |
dc.subject.keywordPlus | PERSISTENCE | - |
dc.subject.keywordAuthor | Medication adherence | - |
dc.subject.keywordAuthor | Letrozole | - |
dc.subject.keywordAuthor | Breast cancer | - |
dc.subject.keywordAuthor | Adjuvant hormone therapy | - |
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