Publications

Detailed Information

Imbalance of Gut Streptococcus, Clostridium, and Akkermansia Determines the Natural Course of Atopic Dermatitis in Infant

Cited 60 time in Web of Science Cited 58 time in Scopus
Authors

Park, Yoon Mee; Lee, So-Yeon; Kang, Mi-Jin; Kim, Bong-Soo; Lee, Min-Jung; Jung, Sung Su; Yoon, Ji Sun; Cho, Hyun-Ju; Lee, Eun; Yang, Song-, I; Seo, Ju-Hee; Kim, Hyo-Bin; Suh, Dong In; Shin, Youn Ho; Kim, Kyung Won; Ahn, Kangmo; Hong, Soo-Jong

Issue Date
2020-03
Publisher
대한천식알레르기학회
Citation
Allergy, Asthma & Immunology Research, Vol.12 No.2, pp.322-337
Abstract
Purpose: The roles of gut microbiota on the natural course of atopic dermatitis (AD) are not yet fully understood. We investigated whether the composition and function of gut microbiota and short-chain fatty acids (SCFAs) at 6 months of age could affect the natural course of AD tip to 24 months in early childhood. Methods: Fecal samples from 132 infants were analyzed using pyrosequencing, including 84 healthy controls, 22 transient AD and 26 persistent AD subjects from the Cohort for Childhood Origin of Asthma and Allergic Diseases (COCOA) birth cohort. The functional profile of the gut microbiome was analyzed by whole-metagenome sequencing. SCFAs were measured using gas chromatography-mass spectrometry. Results: Low levels of Streptococcus and high amounts of Akkermansia were evident in transient All cases, and low Clostridium, Akkermansia and high Streptococcus were found in children with persistent AD. The relative abundance of Streptococcus positively correlated with scoring of AD (SCORAD) score, whereas that of Clostridium negatively correlated with SCORAD score. The persistent All group showed decreased gut microbial functional genes related to oxidative phosphorylation compared with healthy controls. Butyrate and valerate levels were lower in transient All infants compared with healthy and persistent AD infants. Conclusions: Compositions, functions and metabolites of the early gut microbiome are related to natural courses of All in infants.
ISSN
2092-7355
URI
https://hdl.handle.net/10371/177933
DOI
https://doi.org/10.4168/aair.2020.12.2.322
Files in This Item:
There are no files associated with this item.
Appears in Collections:

Altmetrics

Item View & Download Count

  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Share