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Dosage, Intensity, and Frequency of Language Therapy for Aphasia: A Systematic Review-Based, Individual Participant Data Network Meta-Analysis
DC Field | Value | Language |
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dc.contributor.author | Brady, Marian C. | - |
dc.contributor.author | Ali, Myzoon | - |
dc.contributor.author | VandenBerg, Kathryn | - |
dc.contributor.author | Williams, Linda J. | - |
dc.contributor.author | Williams, Louise R. | - |
dc.contributor.author | Abo, Masahiro | - |
dc.contributor.author | Becker, Frank | - |
dc.contributor.author | Bowen, Audrey | - |
dc.contributor.author | Branden-burg, Caitlin | - |
dc.contributor.author | Breitenstein, Caterina | - |
dc.contributor.author | Bruehl, Stefanie | - |
dc.contributor.author | Copland, David A. | - |
dc.contributor.author | Cranfill, Tamara B. | - |
dc.contributor.author | Di Pietro-Bachmann, Marie | - |
dc.contributor.author | Enderby, Pamela | - |
dc.contributor.author | Fillingham, Joanne | - |
dc.contributor.author | Galli, Federica Lucia | - |
dc.contributor.author | Gandolfi, Marialuisa | - |
dc.contributor.author | Glize, Bertrand | - |
dc.contributor.author | Godecke, Erin | - |
dc.contributor.author | Hawkins, Neil | - |
dc.contributor.author | Hilari, Katerina | - |
dc.contributor.author | Hinckley, Jacqueline | - |
dc.contributor.author | Horton, Simon | - |
dc.contributor.author | Howard, David | - |
dc.contributor.author | Jaecks, Petra | - |
dc.contributor.author | Jefferies, Elizabeth | - |
dc.contributor.author | Jesus, Luis M. T. | - |
dc.contributor.author | Kambanaros, Maria | - |
dc.contributor.author | Kang, Eun Kyoung | - |
dc.contributor.author | Khedr, Eman M. | - |
dc.contributor.author | Kong, Anthony Pak-Hin | - |
dc.contributor.author | Kukkonen, Tarja | - |
dc.contributor.author | Laganaro, Marina | - |
dc.contributor.author | Ralph, Matthew A. Lambon | - |
dc.contributor.author | Laska, Ann Charlotte | - |
dc.contributor.author | Leemann, Beatrice | - |
dc.contributor.author | Leff, Alexander P. | - |
dc.contributor.author | Lima, Roxele R. | - |
dc.contributor.author | Lorenz, Antje | - |
dc.contributor.author | MacWhinney, Brian | - |
dc.contributor.author | Marshall, Rebecca Shisler | - |
dc.contributor.author | Mattioli, Flavia | - |
dc.contributor.author | MaviS, ilknur | - |
dc.contributor.author | Meinzer, Marcus | - |
dc.contributor.author | Nilipour, Reza | - |
dc.contributor.author | Noe, Enrique | - |
dc.contributor.author | Paik, Nam-Jong | - |
dc.contributor.author | Palmer, Rebecca | - |
dc.contributor.author | Papathanasiou, Ilias | - |
dc.contributor.author | Patricio, Brigida | - |
dc.contributor.author | Martins, Isabel Pavao | - |
dc.contributor.author | Price, Cathy | - |
dc.contributor.author | Jakovac, Tatjana Prizl | - |
dc.contributor.author | Rochon, Elizabeth | - |
dc.contributor.author | Rose, Miranda L. | - |
dc.contributor.author | Rosso, Charlotte | - |
dc.contributor.author | Rubi-Fessen, Ilona | - |
dc.contributor.author | Ruiter, Marina B. | - |
dc.contributor.author | Snell, Claerwen | - |
dc.contributor.author | Stahl, Benjamin | - |
dc.contributor.author | Szaf-larski, Jerzy P. | - |
dc.contributor.author | Thomas, Shirley A. | - |
dc.contributor.author | Van de Sandt-Koenderman, Mieke | - |
dc.contributor.author | van der Meulen, Ineke | - |
dc.contributor.author | Visch-Brink, Evy | - |
dc.contributor.author | Worrall, Linda | - |
dc.contributor.author | Wright, Heather Harris | - |
dc.date.accessioned | 2022-04-12T04:34:23Z | - |
dc.date.available | 2022-04-12T04:34:23Z | - |
dc.date.created | 2022-03-22 | - |
dc.date.issued | 2022-03 | - |
dc.identifier.citation | Stroke, Vol.29 No.2, pp.956-967 | - |
dc.identifier.issn | 0039-2499 | - |
dc.identifier.uri | https://hdl.handle.net/10371/177982 | - |
dc.description.abstract | BACKGROUND AND PURPOSE: Optimizing speech and language therapy (SLT) regimens for maximal aphasia recovery is a clinical research priority. We examined associations between SLT intensity (hours/week), dosage (total hours), frequency (days/week), duration (weeks), delivery (face to face, computer supported, individual tailoring, and home practice), content, and language outcomes for people with aphasia. METHODS: Databases including MEDLINE and Embase were searched (inception to September 2015). Published, unpublished, and emerging trials including SLT and >= 10 individual participant data on aphasia, language outcomes, and time post-onset were selected. Patient-level data on stroke, language, SLT, and trial risk of bias were independently extracted. Outcome measurement scores were standardized. A statistical inferencing, one-stage, random effects, network meta-analysis approach filtered individual participant data into an optimal model examining SLT regimen for overall language, auditory comprehension, naming, and functional communication pre-post intervention gains, adjusting for a priori-defined covariates (age, sex, time poststroke, and baseline aphasia severity), reporting estimates of mean change scores (95% CI). RESULTS: Data from 959 individual participant data (25 trials) were included. Greatest gains in overall language and comprehension were associated with >20 to 50 hours SLT dosage (18.37 [10.58-26.16] Western Aphasia Battery-Aphasia Quotient; 5.23 [1.51-8.95] Aachen Aphasia Test-Token Test). Greatest clinical overall language, functional communication, and comprehension gains were associated with 2 to 4 and 9+ SLT hours/week. Greatest clinical gains were associated with frequent SLT for overall language, functional communication (3-5+ days/week), and comprehension (4-5 days/week). Evidence of comprehension gains was absent for SLT <= 20 hours, <3 hours/week, and <= 3 days/week. Mixed receptive-expressive therapy, functionally tailored, with prescribed home practice was associated with the greatest overall gains. Relative variance was <30%. Risk of trial bias was low to moderate; low for meta-biases. CONCLUSIONS: Greatest language recovery was associated with frequent, functionally tailored, receptive-expressive SLT, with prescribed home practice at a greater intensity and duration than reports of usual clinical services internationally. These exploratory findings suggest critical therapeutic ranges, informing hypothesis-testing trials and tailoring of clinical services. Registration: URL: ; Unique identifier: CRD42018110947. | - |
dc.language | 영어 | - |
dc.publisher | Lippincott Williams & Wilkins Ltd. | - |
dc.title | Dosage, Intensity, and Frequency of Language Therapy for Aphasia: A Systematic Review-Based, Individual Participant Data Network Meta-Analysis | - |
dc.type | Article | - |
dc.identifier.doi | 10.1161/STROKEAHA.121.035216 | - |
dc.citation.journaltitle | Stroke | - |
dc.identifier.wosid | 000760970600056 | - |
dc.identifier.scopusid | 2-s2.0-85125553790 | - |
dc.citation.endpage | 967 | - |
dc.citation.number | 2 | - |
dc.citation.startpage | 956 | - |
dc.citation.volume | 29 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Paik, Nam-Jong | - |
dc.type.docType | Review | - |
dc.description.journalClass | 1 | - |
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