Publications
Detailed Information
Fate of Surgical Patients with Small Nonfunctioning Pancreatic Neuroendocrine Tumors: An International Study Using Multi-Institutional Registries
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Han, In Woong | - |
dc.contributor.author | Park, Jangho | - |
dc.contributor.author | Park, Eun Young | - |
dc.contributor.author | Yoon, So Jeong | - |
dc.contributor.author | Jin, Gang | - |
dc.contributor.author | Hwang, Dae Wook | - |
dc.contributor.author | Jiang, Kuirong | - |
dc.contributor.author | Kwon, Wooil | - |
dc.contributor.author | Xu, Xuefeng | - |
dc.contributor.author | Heo, Jin Seok | - |
dc.contributor.author | Fu, De-Liang | - |
dc.contributor.author | Lee, Woo Jung | - |
dc.contributor.author | Bai, Xueli | - |
dc.contributor.author | Yoon, Yoo-Seok | - |
dc.contributor.author | Yang, Yin-Mo | - |
dc.contributor.author | Ahn, Keun Soo | - |
dc.contributor.author | Yuan, Chunhui | - |
dc.contributor.author | Lee, Hyeon Kook | - |
dc.contributor.author | Sun, Bei | - |
dc.contributor.author | Park, Eun Kyu | - |
dc.contributor.author | Lee, Seung Eun | - |
dc.contributor.author | Kang, Sunghwa | - |
dc.contributor.author | Lou, Wenhui | - |
dc.contributor.author | Park, Sang-Jae | - |
dc.date.accessioned | 2022-04-13T02:40:14Z | - |
dc.date.available | 2022-04-13T02:40:14Z | - |
dc.date.created | 2022-03-21 | - |
dc.date.issued | 2022-02 | - |
dc.identifier.citation | Cancers, Vol.14 No.4, p. 1038 | - |
dc.identifier.issn | 2072-6694 | - |
dc.identifier.uri | https://hdl.handle.net/10371/178009 | - |
dc.description.abstract | Simple Summary No consensus has been reached regarding whether nonmetastatic nonfunctioning neuroendocrine tumors of the pancreas (NF-pNETs) <= 2 cm should be resected or observed. In this retrospective international multicenter study, 483 patients who underwent resection for NF-pNETs <= 2 cm in 18 institutions from 2000 to 2017 were enrolled and their medical records were reviewed. Tumor size > 1.5 cm, Ki-67 index >= 3%, and nodal metastasis were independent adverse prognostic factors for survival after multivariable analysis. NF-pNET patients with tumors <= 1.5 cm can be observed if the preoperative Ki-67 index is under 3%, and if nodal metastasis is not suspected in preoperative radiologic studies. These findings support the clinical use to make decisions about small NF-pNETs. Several treatment guidelines for sporadic, nonmetastatic nonfunctioning neuroendocrine tumors of the pancreas (NF-pNETs) have recommended resection, however, tumors <= 2 cm do not necessarily need surgery. This study aims to establish a surgical treatment plan for NF-pNETs <= 2 cm. From 2000 to 2017, 483 patients who underwent resection for NF-pNETs <= 2 cm in 18 institutions from Korea and China were enrolled and their medical records were reviewed. The median age was 56 (range 16-80) years. The 10-year overall survival rate (10Y-OS) and recurrence-free survival rate (10Y-RFS) were 89.8 and 93.1%, respectively. In multivariable analysis, tumor size (>1.5 cm; HR 4.28, 95% CI 1.80-10.18, p = 0.001) and nodal metastasis (HR 3.32, 95% CI 1.29-8.50, p = 0.013) were independent adverse prognostic factors for OS. Perineural invasion (HR 4.36, 95% CI 1.48-12.87, p = 0.008) and high Ki-67 index (>= 3%; HR 9.06, 95% CI 3.01-27.30, p < 0.001) were independent prognostic factors for poor RFS. NF-pNETs <= 2 cm showed unfavorable prognosis after resection when the tumor was larger than 1.5 cm, Ki-67 index >= 3%, or nodal metastasis was present. NF-pNET patients with tumors <= 1.5 cm can be observed if the preoperative Ki-67 index is under 3%, and if nodal metastasis is not suspected in preoperative radiologic studies. These findings support the clinical use to make decisions about small NF-pNETs. | - |
dc.language | 영어 | - |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | - |
dc.title | Fate of Surgical Patients with Small Nonfunctioning Pancreatic Neuroendocrine Tumors: An International Study Using Multi-Institutional Registries | - |
dc.type | Article | - |
dc.identifier.doi | 10.3390/cancers14041038 | - |
dc.citation.journaltitle | Cancers | - |
dc.identifier.wosid | 000767558900001 | - |
dc.identifier.scopusid | 2-s2.0-85125087909 | - |
dc.citation.number | 4 | - |
dc.citation.startpage | 1038 | - |
dc.citation.volume | 14 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Yoon, Yoo-Seok | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.