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The SARS-CoV-2 RNA interactome
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Sungyul | - |
dc.contributor.author | Lee, Young-suk | - |
dc.contributor.author | Choi, Yeon | - |
dc.contributor.author | Son, Ahyeon | - |
dc.contributor.author | Park, Youngran | - |
dc.contributor.author | Lee, Kyung-Min | - |
dc.contributor.author | Kim, Jeesoo | - |
dc.contributor.author | Kim, Jong-Seo | - |
dc.contributor.author | Kim, V. Narry | - |
dc.date.accessioned | 2022-04-15T07:59:27Z | - |
dc.date.available | 2022-04-15T07:59:27Z | - |
dc.date.created | 2021-07-23 | - |
dc.date.created | 2021-07-23 | - |
dc.date.created | 2021-07-23 | - |
dc.date.created | 2021-07-23 | - |
dc.date.created | 2021-07-23 | - |
dc.date.created | 2021-07-23 | - |
dc.date.created | 2021-07-23 | - |
dc.date.issued | 2021-07 | - |
dc.identifier.citation | Molecular Cell, Vol.81 No.13, pp.2838-2850 | - |
dc.identifier.issn | 1097-2765 | - |
dc.identifier.other | 138169 | - |
dc.identifier.uri | https://hdl.handle.net/10371/178027 | - |
dc.description.abstract | SARS-CoV-2 is an RNA virus whose success as a pathogen relies on its abilities to repurpose host RNA -binding proteins (RBPs) and to evade antiviral RBPs. To uncover the SARS-CoV-2 RNA interactome, we here develop a robust ribonucleoprotein (RNP) capture protocol and identify 109 host factors that directly bind to SARS-CoV-2 RNAs. Applying RNP capture on another coronavirus, HCoV-OC43, revealed evolutionarily conserved interactions between coronaviral RNAs and host proteins. Transcriptome analyses and knockdown experiments delineated 17 antiviral RBPs, including ZC3HAV1, TRIM25, PARP12, and SHFL, and 8 pro viral RBPs, such as EIF3D and CSDE1, which are responsible for co-opting multiple steps of the mRNA life cycle. This also led to the identification of LARP1, a downstream target of the mTOR signaling pathway, as an antiviral host factor that interacts with the SARS-CoV-2 RNAs. Overall, this study provides a comprehensive list of RBPs regulating coronaviral replication and opens new avenues for therapeutic interventions. | - |
dc.language | 영어 | - |
dc.publisher | Cell Press | - |
dc.title | The SARS-CoV-2 RNA interactome | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 김빛내리 | - |
dc.identifier.doi | 10.1016/j.molcel.2021.04.022 | - |
dc.citation.journaltitle | Molecular Cell | - |
dc.identifier.wosid | 000671130000003 | - |
dc.identifier.scopusid | 2-s2.0-85105795237 | - |
dc.citation.endpage | 2850 | - |
dc.citation.number | 13 | - |
dc.citation.startpage | 2838 | - |
dc.citation.volume | 81 | - |
dc.identifier.sci | 000671130000003 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Kim, Jong-Seo | - |
dc.contributor.affiliatedAuthor | Kim, V. Narry | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | CORONAVIRUS | - |
dc.subject.keywordPlus | TRANSLATION | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordPlus | INTERFERON | - |
dc.subject.keywordPlus | NSP9 | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | REPLICATION | - |
dc.subject.keywordPlus | MODULATION | - |
dc.subject.keywordAuthor | coronavirus | - |
dc.subject.keywordAuthor | COVID-19 | - |
dc.subject.keywordAuthor | HCoV-OC43 | - |
dc.subject.keywordAuthor | LARP1 | - |
dc.subject.keywordAuthor | mass spectrometry | - |
dc.subject.keywordAuthor | RNA | - |
dc.subject.keywordAuthor | RNA interactome capture | - |
dc.subject.keywordAuthor | RNA-binding proteins | - |
dc.subject.keywordAuthor | SARS-CoV-2 | - |
dc.subject.keywordAuthor | virus | - |
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