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Coordinate regulation of the senescent state by selective autophagy
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Yeonghyeon | - |
dc.contributor.author | Kim, Jaejin | - |
dc.contributor.author | Kim, Mi-Sung | - |
dc.contributor.author | Kwon, Yoojin | - |
dc.contributor.author | Shin, Sanghee | - |
dc.contributor.author | Yi, Hyerim | - |
dc.contributor.author | Kim, Hyeonkyeong | - |
dc.contributor.author | Chang, Moon Jong | - |
dc.contributor.author | Chang, Chong Bum | - |
dc.contributor.author | Kang, Seung-Baik | - |
dc.contributor.author | Kim, V. Narry | - |
dc.contributor.author | Kim, Jin-Hong | - |
dc.contributor.author | Kim, Jong-Seo | - |
dc.contributor.author | Elledge, Stephen J. | - |
dc.contributor.author | Kang, Chanhee | - |
dc.date.accessioned | 2022-04-15T07:59:28Z | - |
dc.date.available | 2022-04-15T07:59:28Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.created | 2021-06-14 | - |
dc.date.created | 2021-06-14 | - |
dc.date.created | 2021-06-14 | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2021-05 | - |
dc.identifier.citation | Developmental Cell, Vol.56 No.10, pp.1512-1525 | - |
dc.identifier.issn | 1534-5807 | - |
dc.identifier.other | 135309 | - |
dc.identifier.uri | https://hdl.handle.net/10371/178028 | - |
dc.description.abstract | Cellular senescence is a complex stress response implicated in aging. Autophagy can suppress senescence but is counterintuitively necessary for full senescence. Although its anti-senescence role is well described, to what extent autophagy contributes to senescence establishment and the underlying mechanisms is poorly understood. Here, we show that selective autophagy of multiple regulatory components coordinates the homeostatic state of senescence. We combined a proteomic analysis of autophagy components with protein stability profiling, identifying autophagy substrate proteins involved in several senescence-related processes. Selective autophagy of KEAP1 promoted redox homeostasis during senescence. Furthermore, selective autophagy limited translational machinery components to ameliorate senescence-associated proteotoxic stress. Lastly, selective autophagy of TNIP1 enhanced senescence-associated inflammation. These selective autophagy networks appear to operate in vivo senescence during human osteoarthritis. Our data highlight a caretaker role of autophagy in the stress support network of senescence through regulated protein stability and unravel the intertwined relationship between two important age-related processes. | - |
dc.language | 영어 | - |
dc.publisher | Cell Press | - |
dc.title | Coordinate regulation of the senescent state by selective autophagy | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 김진홍 | - |
dc.contributor.AlternativeAuthor | 김빛내리 | - |
dc.contributor.AlternativeAuthor | 김종서 | - |
dc.contributor.AlternativeAuthor | 강찬희 | - |
dc.identifier.doi | 10.1016/j.devcel.2021.04.008 | - |
dc.citation.journaltitle | Developmental Cell | - |
dc.identifier.wosid | 000652829400013 | - |
dc.identifier.scopusid | 2-s2.0-85105563939 | - |
dc.citation.endpage | 1525 | - |
dc.citation.number | 10 | - |
dc.citation.startpage | 1512 | - |
dc.citation.volume | 56 | - |
dc.identifier.sci | 000652829400013 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Chang, Chong Bum | - |
dc.contributor.affiliatedAuthor | Kang, Seung-Baik | - |
dc.contributor.affiliatedAuthor | Kim, V. Narry | - |
dc.contributor.affiliatedAuthor | Kim, Jin-Hong | - |
dc.contributor.affiliatedAuthor | Kim, Jong-Seo | - |
dc.contributor.affiliatedAuthor | Kang, Chanhee | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | CELLULAR SENESCENCE | - |
dc.subject.keywordPlus | COMPUTATIONAL PLATFORM | - |
dc.subject.keywordPlus | A20-BINDING INHIBITOR | - |
dc.subject.keywordPlus | SECRETORY PHENOTYPE | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | DEGRADATION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordAuthor | aging | - |
dc.subject.keywordAuthor | autophagy | - |
dc.subject.keywordAuthor | cellular senescence | - |
dc.subject.keywordAuthor | inflammation | - |
dc.subject.keywordAuthor | oxidative stress | - |
dc.subject.keywordAuthor | proteostasis | - |
dc.subject.keywordAuthor | regulated protein stability | - |
dc.subject.keywordAuthor | selective autophagy | - |
dc.subject.keywordAuthor | stress response | - |
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