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Telomeres reforged with non-telomeric sequences in mouse embryonic stem cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Chuna | - |
dc.contributor.author | Sung, Sanghyun | - |
dc.contributor.author | Kim, Jong-Seo | - |
dc.contributor.author | Lee, Hyunji | - |
dc.contributor.author | Jung, Yoonseok | - |
dc.contributor.author | Shin, Sanghee | - |
dc.contributor.author | Kim, Eunkyeong | - |
dc.contributor.author | Seo, Jenny J. | - |
dc.contributor.author | Kim, Jun | - |
dc.contributor.author | Kim, Daeun | - |
dc.contributor.author | Niida, Hiroyuki | - |
dc.contributor.author | Kim, V. Narry | - |
dc.contributor.author | Park, Daechan | - |
dc.contributor.author | Lee, Junho | - |
dc.date.accessioned | 2022-04-15T07:59:36Z | - |
dc.date.available | 2022-04-15T07:59:36Z | - |
dc.date.created | 2021-05-27 | - |
dc.date.created | 2021-05-27 | - |
dc.date.created | 2021-05-27 | - |
dc.date.created | 2021-05-27 | - |
dc.date.created | 2021-05-27 | - |
dc.date.issued | 2021-02 | - |
dc.identifier.citation | Nature Communications, Vol.12 No.1, p. 1097 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.other | 132963 | - |
dc.identifier.uri | https://hdl.handle.net/10371/178036 | - |
dc.description.abstract | Telomeres are part of a highly refined system for maintaining the stability of linear chromosomes. Most telomeres rely on simple repetitive sequences and telomerase enzymes to protect chromosomal ends; however, in some species or telomerase-defective situations, an alternative lengthening of telomeres (ALT) mechanism is used. ALT mainly utilises recombination-based replication mechanisms and the constituents of ALT-based telomeres vary depending on models. Here we show that mouse telomeres can exploit non-telomeric, unique sequences in addition to telomeric repeats. We establish that a specific subtelomeric element, the mouse template for ALT (mTALT), is used for repairing telomeric DNA damage as well as for composing portions of telomeres in ALT-dependent mouse embryonic stem cells. Epigenomic and proteomic analyses before and after ALT activation reveal a high level of non-coding mTALT transcripts despite the heterochromatic nature of mTALT-based telomeres. After ALT activation, the increased HMGN1, a non-histone chromosomal protein, contributes to the maintenance of telomere stability by regulating telomeric transcription. These findings provide a molecular basis to study the evolution of new structures in telomeres. Telomeres can be maintained by a telomerase-independent mechanism called an alternative lengthening of telomeres (ALT). Here the authors use mouse Terc (telomerase RNA) knockout embryonic cells and provide longitudinal analysis of ALT telomeres maintained with non-telomeric sequences. | - |
dc.language | 영어 | - |
dc.publisher | Nature Publishing Group | - |
dc.title | Telomeres reforged with non-telomeric sequences in mouse embryonic stem cells | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 김빛내리 | - |
dc.contributor.AlternativeAuthor | 김종서 | - |
dc.contributor.AlternativeAuthor | 이준호 | - |
dc.identifier.doi | 10.1038/s41467-021-21341-x | - |
dc.citation.journaltitle | Nature Communications | - |
dc.identifier.wosid | 000621232800016 | - |
dc.identifier.scopusid | 2-s2.0-85100884760 | - |
dc.citation.number | 1 | - |
dc.citation.startpage | 1097 | - |
dc.citation.volume | 12 | - |
dc.identifier.sci | 000621232800016 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Kim, Jong-Seo | - |
dc.contributor.affiliatedAuthor | Kim, V. Narry | - |
dc.contributor.affiliatedAuthor | Lee, Junho | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | DNA HYBRIDS | - |
dc.subject.keywordPlus | R-LOOPS | - |
dc.subject.keywordPlus | MAINTENANCE | - |
dc.subject.keywordPlus | TRANSCRIPTION | - |
dc.subject.keywordPlus | DISCOVERY | - |
dc.subject.keywordPlus | PROVIDES | - |
dc.subject.keywordPlus | REVEALS | - |
dc.subject.keywordPlus | ABSENCE | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordPlus | REPAIR | - |
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