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microRNA-30a arbitrates intestinal-type early gastric carcinogenesis by directly targeting ITGA2
DC Field | Value | Language |
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dc.contributor.author | Min, Jimin | - |
dc.contributor.author | Han, Tae-Su | - |
dc.contributor.author | Sohn, Yoojin | - |
dc.contributor.author | Shimizu, Takahiro | - |
dc.contributor.author | Choi, Boram | - |
dc.contributor.author | Bae, Seong-Woo | - |
dc.contributor.author | Hur, Keun | - |
dc.contributor.author | Kong, Seong-Ho | - |
dc.contributor.author | Suh, Yun-Suhk | - |
dc.contributor.author | Lee, Hyuk-Joon | - |
dc.contributor.author | Kim, Jang-Seong | - |
dc.contributor.author | Min, Jeong-Ki | - |
dc.contributor.author | Kim, Woo-Ho | - |
dc.contributor.author | Kim, V. Narry | - |
dc.contributor.author | Choi, Eunyoung | - |
dc.contributor.author | Goldenring, James R. | - |
dc.contributor.author | Yang, Han-Kwang | - |
dc.date.accessioned | 2022-04-15T07:59:41Z | - |
dc.date.available | 2022-04-15T07:59:41Z | - |
dc.date.created | 2021-01-25 | - |
dc.date.created | 2021-01-25 | - |
dc.date.created | 2021-01-25 | - |
dc.date.created | 2021-01-25 | - |
dc.date.issued | 2020-07 | - |
dc.identifier.citation | Gastric Cancer, Vol.23 No.4, pp.600-613 | - |
dc.identifier.issn | 1436-3291 | - |
dc.identifier.other | 121481 | - |
dc.identifier.uri | https://hdl.handle.net/10371/178040 | - |
dc.description.abstract | Background Spasmolytic polypeptide-expressing metaplasia (SPEM) is considered a precursor lesion of intestinal metaplasia and intestinal-type gastric cancer (GC), but little is known about microRNA alterations during metaplasia and GC developments. Here, we investigate miR-30a expression in gastric lesions and identify its novel target gene which is associated with the intestinal-type GC. Methods We conducted in situ hybridization and qRT-PCR to determine miR-30a expression in gastric tissues. miR-30a functions were determined through induction or inhibition of miR-30a in GC cell lines. A gene microarray was utilized to confirm miR-30a target genes in GC, and siRNA-mediated target gene suppression and immunostaining were performed. The Cancer Genome Atlas data were utilized to validate gene expressions. Results We found down-regulation of miR-30a during chief cell transdifferentiation into SPEM. MiR-30a level was also reduced in the early stage of GC, and its level was maintained in advanced GC. We identified a novel target gene of miR-30a and ITGA2, and our results showed that either ectopic expression of miR-30a or ITGA2 knockdown suppressed GC cell proliferation, migration, and tumorigenesis. Levels of ITGA2 inversely correlated with levels of miR-30a in human intestinal-type GC. Conclusion We found down-regulation of miR-30a in preneoplastic lesions and its tumor-suppressive functions by targeting ITGA2 in GC. The level of ITGA2, which functions as an oncogene, was up-regulated in human GC. The results of this study suggest that coordination of the miR-30a-ITGA2 axis may serve as an important mechanism in the development of gastric precancerous lesions and intestinal-type GC. | - |
dc.language | 영어 | - |
dc.publisher | Springer Verlag | - |
dc.title | microRNA-30a arbitrates intestinal-type early gastric carcinogenesis by directly targeting ITGA2 | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 김빛내리 | - |
dc.identifier.doi | 10.1007/s10120-020-01052-w | - |
dc.citation.journaltitle | Gastric Cancer | - |
dc.identifier.wosid | 000517022900001 | - |
dc.identifier.scopusid | 2-s2.0-85080988873 | - |
dc.citation.endpage | 613 | - |
dc.citation.number | 4 | - |
dc.citation.startpage | 600 | - |
dc.citation.volume | 23 | - |
dc.identifier.sci | 000517022900001 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Lee, Hyuk-Joon | - |
dc.contributor.affiliatedAuthor | Kim, Woo-Ho | - |
dc.contributor.affiliatedAuthor | Kim, V. Narry | - |
dc.contributor.affiliatedAuthor | Yang, Han-Kwang | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | POLYPEPTIDE-EXPRESSING METAPLASIA | - |
dc.subject.keywordPlus | DECREASES MULTIDRUG-RESISTANCE | - |
dc.subject.keywordPlus | TO-MESENCHYMAL TRANSITION | - |
dc.subject.keywordPlus | CANCER CELLS | - |
dc.subject.keywordPlus | COLORECTAL-CANCER | - |
dc.subject.keywordPlus | TUMOR-SUPPRESSOR | - |
dc.subject.keywordPlus | MIR-30A | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | PROMOTES | - |
dc.subject.keywordPlus | INVASION | - |
dc.subject.keywordAuthor | miR-30a | - |
dc.subject.keywordAuthor | ITGA2 | - |
dc.subject.keywordAuthor | Metaplasia | - |
dc.subject.keywordAuthor | Gastric cancer | - |
dc.subject.keywordAuthor | Tumor suppressor | - |
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