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Interaction of Nrf2 with dimeric STAT3 induces IL-23 expression: Implications for breast cancer progression
DC Field | Value | Language |
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dc.contributor.author | Kim, Su-Jung | - |
dc.contributor.author | Saeidi, Soma | - |
dc.contributor.author | Cho, Nam-Chul | - |
dc.contributor.author | Kim, Seung Hyeon | - |
dc.contributor.author | Lee, Han-Byoel | - |
dc.contributor.author | Han, Wonshik | - |
dc.contributor.author | Noh, Dong-Young | - |
dc.contributor.author | Surh, Young-Joon | - |
dc.date.accessioned | 2022-04-18T02:22:52Z | - |
dc.date.available | 2022-04-18T02:22:52Z | - |
dc.date.created | 2021-03-09 | - |
dc.date.created | 2021-03-09 | - |
dc.date.issued | 2021-03-01 | - |
dc.identifier.citation | Cancer Letters, Vol.500, pp.147-160 | - |
dc.identifier.issn | 0304-3835 | - |
dc.identifier.other | 125073 | - |
dc.identifier.uri | https://hdl.handle.net/10371/178054 | - |
dc.description.abstract | Persistent activation of STAT3 and Nrf2 is considered to stimulate the aggressive behavior of basal-like breast cancer (BLBC). However, the precise mechanism underlying sustained overactivation of these transcription factors and their roles in breast cancer progression remain elusive. Analysis of the TCGA multi-omics data showed that high levels of STAT3 and Nrf2 mRNA were correlated with elevated expression of P-STAT3(Y705) and Nrf2 target proteins in breast cancer patients. Our present study demonstrates a unique interaction between Nrf2 and STAT3 in the maintenance and progression of BLBC. RNA sequencing analysis identified the gene encoding IL-23A upregulated by concurrent binding of STAT3 and Nrf2 to its promoter. IL-23A depletion also showed the similar phenotypic changes to those caused by double knockdown of both transcription factors. In conclusion, the STAT3-Nrf2 interaction accelerates BLBC growth and progression by augmenting IL-23A expression, which underscores the importance of subtype-specific molecular pathways in human breast cancer.Y | - |
dc.language | 영어 | - |
dc.publisher | Elsevier BV | - |
dc.title | Interaction of Nrf2 with dimeric STAT3 induces IL-23 expression: Implications for breast cancer progression | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 서영준 | - |
dc.contributor.AlternativeAuthor | 한원식 | - |
dc.contributor.AlternativeAuthor | 노동영 | - |
dc.identifier.doi | 10.1016/j.canlet.2020.11.047 | - |
dc.citation.journaltitle | Cancer Letters | - |
dc.identifier.wosid | 000607200800014 | - |
dc.identifier.scopusid | 2-s2.0-85098155743 | - |
dc.citation.endpage | 160 | - |
dc.citation.startpage | 147 | - |
dc.citation.volume | 500 | - |
dc.identifier.sci | 000607200800014 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Han, Wonshik | - |
dc.contributor.affiliatedAuthor | Noh, Dong-Young | - |
dc.contributor.affiliatedAuthor | Surh, Young-Joon | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | SIGNALING PATHWAY | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | PROMOTES | - |
dc.subject.keywordPlus | TRANSCRIPTION | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | INHIBITOR | - |
dc.subject.keywordPlus | CARCINOMA | - |
dc.subject.keywordPlus | TRANSACTIVATION | - |
dc.subject.keywordAuthor | Nrf2 | - |
dc.subject.keywordAuthor | STAT3 | - |
dc.subject.keywordAuthor | IL-23A | - |
dc.subject.keywordAuthor | Breast cancer | - |
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