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15-Deoxy-Δ12,14-prostaglandin J2 Upregulates VEGF Expression via NRF2 and Heme Oxygenase-1 in Human Breast Cancer Cells : 15-Deoxy-Delta(12,14)-prostaglandin J(2) Upregulates VEGF Expression via NRF2 and Heme Oxygenase-1 in Human Breast Cancer Cells
DC Field | Value | Language |
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dc.contributor.author | Kim, Eun-Hee | - |
dc.contributor.author | Kim, Su-Jung | - |
dc.contributor.author | Na, Hye-Kyung | - |
dc.contributor.author | Han, Wonshik | - |
dc.contributor.author | Kim, Nam-Jung | - |
dc.contributor.author | Suh, Young-Ger | - |
dc.contributor.author | Surh, Young-Joon | - |
dc.date.accessioned | 2022-04-18T02:23:01Z | - |
dc.date.available | 2022-04-18T02:23:01Z | - |
dc.date.created | 2021-05-18 | - |
dc.date.created | 2021-05-18 | - |
dc.date.issued | 2021-03 | - |
dc.identifier.citation | Cells, Vol.10 No.3, pp.526-24 | - |
dc.identifier.issn | 2073-4409 | - |
dc.identifier.other | 131891 | - |
dc.identifier.uri | https://hdl.handle.net/10371/178061 | - |
dc.description.abstract | There is a plethora of evidence to support that inflammation is causally linked to carcinogenesis. Cyclooxygenase-2 (COX-2), a rate-limiting enzyme in the biosynthesis of prostaglandins, is inappropriately overexpressed in various cancers and hence recognized as one of the hallmarks of chronic inflammation-associated malignancies. However, the mechanistic role of COX-2 as a link between inflammation and cancer remains largely undefined. In this study, we found that 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)), one of the final products of COX-2, induced upregulation of vascular endothelial growth factor (VEGF) and capillary formation and migration through nuclear factor erythroid 2-related factor 2 (NRF2)-dependent heme oxygenase-1 (HO-1) induction in MCF-7 cells. Analysis of the publicly available TCGA data set showed that high mRNA levels of both COX-2 and NRF2 correlated with the poor clinical outcomes in breast cancer patients. Moreover, human tissue analysis showed that the levels of 15d-PGJ(2) as well the expression of COX-2, NRF2, and HO-1 were found to be increased in human breast cancer tissues. In conclusion, the elevated levels of 15d-PGJ(2) during inflammatory response activate VEGF expression through NRF2-driven induction of HO-1 in human breast cancer cells, proposing a novel mechanism underlying the oncogenic function of 15d-PGJ(2). | - |
dc.language | 영어 | - |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | - |
dc.title | 15-Deoxy-Δ12,14-prostaglandin J2 Upregulates VEGF Expression via NRF2 and Heme Oxygenase-1 in Human Breast Cancer Cells | - |
dc.title.alternative | 15-Deoxy-Delta(12,14)-prostaglandin J(2) Upregulates VEGF Expression via NRF2 and Heme Oxygenase-1 in Human Breast Cancer Cells | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 서영준 | - |
dc.identifier.doi | 10.3390/cells10030526 | - |
dc.citation.journaltitle | Cells | - |
dc.identifier.wosid | 000633463900001 | - |
dc.identifier.scopusid | 2-s2.0-85103863279 | - |
dc.citation.endpage | 24 | - |
dc.citation.number | 3 | - |
dc.citation.startpage | 526 | - |
dc.citation.volume | 10 | - |
dc.identifier.sci | 000633463900001 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Han, Wonshik | - |
dc.contributor.affiliatedAuthor | Surh, Young-Joon | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordAuthor | 15-Deoxy-Delta(12),(14)-prostaglandin J(2) | - |
dc.subject.keywordAuthor | NRF2 | - |
dc.subject.keywordAuthor | heme oxygenase-1 | - |
dc.subject.keywordAuthor | VEGF | - |
dc.subject.keywordAuthor | breast cancer | - |
dc.subject.keywordAuthor | MCF-7 cells | - |
dc.subject.keywordAuthor | angiogenesis | - |
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