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Mitochondrial DNA editing in mice with DddA-TALE fusion deaminases
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Hyunji | - |
dc.contributor.author | Lee, Seonghyun | - |
dc.contributor.author | Baek, Gayoung | - |
dc.contributor.author | Kim, Annie | - |
dc.contributor.author | Kang, Beum-Chang | - |
dc.contributor.author | Seo, Huiyun | - |
dc.contributor.author | Kim, Jin-Soo | - |
dc.date.accessioned | 2022-04-20T10:55:46Z | - |
dc.date.available | 2022-04-20T10:55:46Z | - |
dc.date.created | 2021-05-21 | - |
dc.date.created | 2021-05-21 | - |
dc.date.created | 2021-05-21 | - |
dc.date.issued | 2021-02-19 | - |
dc.identifier.citation | Nature Communications, Vol.12 No.1, p. 1190 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.other | 132089 | - |
dc.identifier.uri | https://hdl.handle.net/10371/179116 | - |
dc.description.abstract | DddA-derived cytosine base editors (DdCBEs), composed of the split interbacterial toxin DddA(tox), transcription activator-like effector (TALE), and uracil glycosylase inhibitor (UGI), enable targeted C-to-T base conversions in mitochondrial DNA (mtDNA). Here, we demonstrate highly efficient mtDNA editing in mouse embryos using custom-designed DdCBEs. We target the mitochondrial gene, MT-ND5 (ND5), which encodes a subunit of NADH dehydrogenase that catalyzes NADH dehydration and electron transfer to ubiquinone, to obtain several mtDNA mutations, including m.G12918A associated with human mitochondrial diseases and m.C12336T that incorporates a premature stop codon, creating mitochondrial disease models in mice and demonstrating a potential for the treatment of mitochondrial disorders. Split DddA-derived base editors fused to TALEs enable mitochondrial DNA editing. Here the authors demonstrate their use in mouse embryos with germline transmission. | - |
dc.language | 영어 | - |
dc.publisher | Nature Publishing Group | - |
dc.title | Mitochondrial DNA editing in mice with DddA-TALE fusion deaminases | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 김진수 | - |
dc.identifier.doi | 10.1038/s41467-021-21464-1 | - |
dc.citation.journaltitle | Nature Communications | - |
dc.identifier.wosid | 000621495300002 | - |
dc.identifier.scopusid | 2-s2.0-85101041088 | - |
dc.citation.number | 1 | - |
dc.citation.startpage | 1190 | - |
dc.citation.volume | 12 | - |
dc.identifier.sci | 000621495300002 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Kim, Jin-Soo | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
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