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DOC-2/hDab-2 inhibits ILK activity and induces anoikis in breast cancer cells through an Akt-independent pathway
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Wang, SC | - |
dc.contributor.author | Makino, K | - |
dc.contributor.author | Xia, WY | - |
dc.contributor.author | Kim, JS | - |
dc.contributor.author | Im, SA | - |
dc.contributor.author | Peng, H | - |
dc.contributor.author | Mok, SC | - |
dc.contributor.author | Singletary, SE | - |
dc.contributor.author | Hung, MC | - |
dc.date.accessioned | 2022-04-26T07:11:47Z | - |
dc.date.available | 2022-04-26T07:11:47Z | - |
dc.date.created | 2022-04-18 | - |
dc.date.created | 2022-04-18 | - |
dc.date.created | 2022-04-18 | - |
dc.date.created | 2022-04-18 | - |
dc.date.issued | 2001-10 | - |
dc.identifier.citation | Oncogene, Vol.20 No.47, pp.6960-6964 | - |
dc.identifier.issn | 0950-9232 | - |
dc.identifier.other | 158763 | - |
dc.identifier.uri | https://hdl.handle.net/10371/179215 | - |
dc.description.abstract | DOC-2/hDab-2 was identified due to the loss of its expression in primary ovarian cancer cells. It is believed that loss of DOC-2/hDab-2 expression is one of the early events of ovarian malignancy. These results suggest a function of DOC-2/hDab-2 as a tumor suppressor. However, it is not clear how DOC-2/hDab-2 negatively regulates cancer cell growth. In this report, we demonstrate that DOC-2/hDab-2 expression in breast cancer cells resulted in sensitivity to suspension-induced cell death (anoikis). This event was associated with the down-regulation of the integrin-linked kinase (ILK) activity. Since ILK is a key factor in regulating the cellular signaling in responding to the extracellular signals through adhesion molecules like integrins, our results indicate that DOC-2/hDab-2 may prevent tumor growth and invasion by modulating the anti-apoptotic ILK pathway. | - |
dc.language | 영어 | - |
dc.publisher | Nature Publishing Group | - |
dc.title | DOC-2/hDab-2 inhibits ILK activity and induces anoikis in breast cancer cells through an Akt-independent pathway | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 임석아 | - |
dc.identifier.doi | 10.1038/sj.onc.1204873 | - |
dc.citation.journaltitle | Oncogene | - |
dc.identifier.wosid | 000171641000018 | - |
dc.identifier.scopusid | 2-s2.0-0035909524 | - |
dc.citation.endpage | 6964 | - |
dc.citation.number | 47 | - |
dc.citation.startpage | 6960 | - |
dc.citation.volume | 20 | - |
dc.identifier.sci | 000171641000018 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Im, SA | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | INTEGRIN-LINKED KINASE | - |
dc.subject.keywordPlus | EPITHELIAL OVARIAN-CANCER | - |
dc.subject.keywordPlus | PHOSPHOINOSITIDE-3-OH KINASE | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | CLONING | - |
dc.subject.keywordPlus | DOMAIN | - |
dc.subject.keywordPlus | B/AKT | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordAuthor | ILK | - |
dc.subject.keywordAuthor | DOC-2/hDab-2 | - |
dc.subject.keywordAuthor | anoikis | - |
dc.subject.keywordAuthor | breast cancer | - |
dc.subject.keywordAuthor | HER-2 | - |
dc.subject.keywordAuthor | neu | - |
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