Publications
Detailed Information
Mobilization kinetics of CD34(+) cells in association with modulation of CD44 and CD31 expression during continuous intravenous administration of G-CSF in normal donors
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, S | - |
dc.contributor.author | Im, SA | - |
dc.contributor.author | Yoo, ES | - |
dc.contributor.author | Nam, EM | - |
dc.contributor.author | Lee, MA | - |
dc.contributor.author | Ahn, JY | - |
dc.contributor.author | Huh, JW | - |
dc.contributor.author | Kim, DY | - |
dc.contributor.author | Lee, SN | - |
dc.contributor.author | Kim, MJ | - |
dc.contributor.author | Lee, SJ | - |
dc.contributor.author | Chung, WS | - |
dc.contributor.author | Seong, CM | - |
dc.date.accessioned | 2022-04-26T07:11:51Z | - |
dc.date.available | 2022-04-26T07:11:51Z | - |
dc.date.created | 2022-04-18 | - |
dc.date.created | 2022-04-18 | - |
dc.date.issued | 2000 | - |
dc.identifier.citation | Stem Cells, Vol.18 No.4, pp.281-286 | - |
dc.identifier.issn | 1066-5099 | - |
dc.identifier.other | 158757 | - |
dc.identifier.uri | https://hdl.handle.net/10371/179219 | - |
dc.description.abstract | The aim of the present study is to evaluate the kinetics of CD34(+) cells and investigate the potential modulation of CD44 and CD31 expression on CD34(+) cells during continuous i.v. administration of G-CSF, thus to elucidate the possible mechanism of peripheral blood progenitor cell (PBPC) mobilization. Fifteen healthy donors were enrolled in this study. G-CSF (10 mu g/kg/day) was administered for four consecutive days through continuous 24-h i.v. infusion. For measurement of complete blood counts, CD34(+) cell levels and their expression of CD44 and CD31, PB sampling was performed immediately before the administration of G-CSP (steady-state) and after 4, 8, 24, 48, 72, 96, and 120 h of G-CSF administration. The percentage and absolute number of CD34(+) cells significantly increased at day 3 (0.55 +/- 0.09%, 51.12 +/- 24.83 x 10(3)/ml) and day 4 (0.47 +/- 0.09%, 46.66 +/- 24.93 x 103/ml), compared to the steady-state level (0.06 +/- 0.09%, 2.03 +/- 5.69 x 103/ml). At day 3 to day 5 following the onset of G-CSF administration, a strong decrease of CD44 and CD31 expression was observed on mobilized CD34(+) cells compared to controls: the relative fluorescence intensity of CD44 and CD31 was, respectively, 50%-70% and 40%-90% lower than that of controls. We conclude that continuous i.v. administration of G-CSF apparently results in more rapid mobilization of CD34(+) cells, and downregulation of CD44 and CD31 on CD34(+) cells is likely to be involved in the mobilization of PBPC after treatment with G-CSF. | - |
dc.language | 영어 | - |
dc.publisher | AlphaMed Press Inc | - |
dc.title | Mobilization kinetics of CD34(+) cells in association with modulation of CD44 and CD31 expression during continuous intravenous administration of G-CSF in normal donors | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 임석아 | - |
dc.identifier.doi | 10.1634/stemcells.18-4-281 | - |
dc.citation.journaltitle | Stem Cells | - |
dc.identifier.wosid | 000088417300006 | - |
dc.identifier.scopusid | 2-s2.0-0033858358 | - |
dc.citation.endpage | 286 | - |
dc.citation.number | 4 | - |
dc.citation.startpage | 281 | - |
dc.citation.volume | 18 | - |
dc.identifier.sci | 000088417300006 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Im, SA | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | COLONY-STIMULATING FACTOR | - |
dc.subject.keywordPlus | BLOOD PROGENITOR CELLS | - |
dc.subject.keywordPlus | PERIPHERAL-BLOOD | - |
dc.subject.keywordPlus | BONE-MARROW | - |
dc.subject.keywordPlus | ALLOGENEIC TRANSPLANTATION | - |
dc.subject.keywordPlus | HEMATOPOIETIC PROGENITORS | - |
dc.subject.keywordPlus | DIFFERENTIAL EXPRESSION | - |
dc.subject.keywordPlus | ADHESION MOLECULES | - |
dc.subject.keywordPlus | NORMAL VOLUNTEERS | - |
dc.subject.keywordPlus | STEM-CELLS | - |
dc.subject.keywordAuthor | continuous iv. G-CSF | - |
dc.subject.keywordAuthor | mobilization kinetics | - |
dc.subject.keywordAuthor | CD34(+) cells | - |
dc.subject.keywordAuthor | CD31 | - |
dc.subject.keywordAuthor | CD44 | - |
dc.subject.keywordAuthor | normal donors | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.