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Chicago sky blue 6B inhibits α-synuclein aggregation and propagation
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Min, Joo-Ok | - |
dc.contributor.author | Strohäker, Timo | - |
dc.contributor.author | Jeong, Byung-Chul | - |
dc.contributor.author | Zweckstetter, Markus | - |
dc.contributor.author | Lee, Seung-Jae | - |
dc.date.accessioned | 2022-05-04T05:47:26Z | - |
dc.date.available | 2022-05-04T05:47:26Z | - |
dc.date.issued | 2022-03-28 | - |
dc.identifier.citation | Molecular Brain, Vol 15(1):27 | ko_KR |
dc.identifier.issn | 1756-6606 | - |
dc.identifier.uri | https://hdl.handle.net/10371/179619 | - |
dc.description.abstract | Abnormal deposition of α-synuclein aggregates in Lewy bodies and Lewy neurites is the hallmark lesion in Parkinsons disease (PD). These aggregates, thought to be the culprit of disease pathogenesis, spread throughout the brain as the disease progresses. Agents that inhibit α-synuclein aggregation and/or spread of aggregates would thus be candidate disease-modifying drugs. Here, we found that Chicago sky blue 6B (CSB) may be such a drug, showing that it inhibits α-synuclein aggregation and cell-to-cell propagation in both in vitro and in vivo models of synucleinopathy. CSB inhibited the fibrillation of α-synuclein in a concentration-dependent manner through direct binding to the N-terminus of α-synuclein. Furthermore, both seeded polymerization and cell-to-cell propagation of α-synuclein were inhibited by CSB treatment. Notably, CSB alleviated behavioral deficits and neuropathological features, such as phospho-α-synuclein and astrogliosis, in A53T α-synuclein transgenic mice. These results indicate that CSB directly binds α-synuclein and inhibits its aggregation, thereby blocking α-synuclein cell-to-cell propagation. | ko_KR |
dc.description.sponsorship | This work was supported by National Research Foundation (NRF) Grants funded by the Korean Government (MEST) (NRF-2018R1A5A2025964, NRF2021R1A2C3012681 to S.-J.L.), and the Korea Healthcare Technology R&D Project, Ministry of Health & Welfare, Republic of Korea (HI19C0256 to S.-J.L.). J.-O.M received a scholarship from the BK21 FOUR education program. MZ was
supported by the DFG Collaborative Research Center SFB860 (project B2). | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BMC | ko_KR |
dc.subject | Chicago sky blue 6B | - |
dc.subject | α-synuclein | - |
dc.subject | Protein aggregation | - |
dc.subject | Aggregate propagation | - |
dc.subject | Parkinson’s disease | - |
dc.title | Chicago sky blue 6B inhibits α-synuclein aggregation and propagation | ko_KR |
dc.type | Article | ko_KR |
dc.identifier.doi | https://doi.org/10.1186/s13041-022-00913-y | ko_KR |
dc.citation.journaltitle | Molecular Brain | ko_KR |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s) | - |
dc.date.updated | 2022-04-03T03:13:26Z | - |
dc.citation.number | 1 | ko_KR |
dc.citation.startpage | 27 | ko_KR |
dc.citation.volume | 15 | ko_KR |
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