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Higher serotonin transporter availability in early‐onset obsessive–compulsive disorder patients undergoing escitalopram treatment: A [11C]DASB PET study : Higher serotonin transporter availability in early-onset obsessive-compulsive disorder patients undergoing escitalopram treatment: A [C-11]DASB PET study
DC Field | Value | Language |
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dc.contributor.author | Lee, Junhee | - |
dc.contributor.author | Kim, Bo-Hyung | - |
dc.contributor.author | Kim, Euitae | - |
dc.contributor.author | Howes, Oliver D. | - |
dc.contributor.author | Cho, Kang Ik Kevin | - |
dc.contributor.author | Yoon, Youngwoo Bryan | - |
dc.contributor.author | Kwon, Jun Soo | - |
dc.date.accessioned | 2022-05-16T05:43:19Z | - |
dc.date.available | 2022-05-16T05:43:19Z | - |
dc.date.created | 2019-06-28 | - |
dc.date.issued | 2018-01 | - |
dc.identifier.citation | Human Psychopharmacology, Vol.33 No.1, p. e2642 | - |
dc.identifier.issn | 0885-6222 | - |
dc.identifier.uri | https://hdl.handle.net/10371/179668 | - |
dc.description.abstract | Objective: Early-onset obsessive-compulsive disorder (EOCD) and late-onset obsessive-compulsive disorder (LOCD) are distinct subtypes of obsessive-compulsive disorder (OCD). OCD patients are treated with serotonin reuptake inhibitors, but the difference in serotonin transporter (SERT) availability between medicated EOCD and LOCD is unexplored yet. Methods: Six EOCD and 6 LOCD patients were enrolled. They underwent serial [C-11]DASB positron emission tomography scans during maintenance therapy with escitalopram, and their plasma concentration of escitalopram was measured simultaneously with the scan. Then, the drug-free binding potential of SERT was calculated by pharmacokinetic-pharmacodynamic modelling. Results: In comparison with LOCD patients, SERT availability was significantly higher in the putamen of EOCD patients (U = 4, p = .026), but not in the caudate nucleus (U=14, p=.589), thalamus (U = 16, p = .818), and dorsal raphe nucleus (U = 7, p = .093). Binding potential of putamen showed a negative correlation (r = -.580, p = .048) with age of onset of the disease, but not with the Yale-Brown Obsessive Compulsive Scale scores. Conclusions: These findings indicate that the earlier the age of onset of OCD, the less serotonergic pathology there is and that this difference remains even after long-term serotonin reuptake inhibitor treatment. Clinically, it might suggest that nonserotonergic treatments would be a better option for EOCD patients. | - |
dc.language | 영어 | - |
dc.publisher | John Wiley & Sons Inc. | - |
dc.title | Higher serotonin transporter availability in early‐onset obsessive–compulsive disorder patients undergoing escitalopram treatment: A [11C]DASB PET study | - |
dc.title.alternative | Higher serotonin transporter availability in early-onset obsessive-compulsive disorder patients undergoing escitalopram treatment: A [C-11]DASB PET study | - |
dc.type | Article | - |
dc.identifier.doi | 10.1002/hup.2642 | - |
dc.citation.journaltitle | Human Psychopharmacology | - |
dc.identifier.wosid | 000423394000001 | - |
dc.identifier.scopusid | 2-s2.0-85037671507 | - |
dc.citation.number | 1 | - |
dc.citation.startpage | e2642 | - |
dc.citation.volume | 33 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Kim, Euitae | - |
dc.contributor.affiliatedAuthor | Kwon, Jun Soo | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
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