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The Link module of human TSG-6 (Link_TSG6) promotes wound healing, suppresses inflammation and improves glandular function in mouse models of Dry Eye Disease
DC Field | Value | Language |
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dc.contributor.author | Oh, Joo Youn | - |
dc.contributor.author | Ryu, Jin Suk | - |
dc.contributor.author | Kim, Hyeon Ji | - |
dc.contributor.author | Kouvatsos, Nikolaos | - |
dc.contributor.author | Dodd, Rebecca J. | - |
dc.contributor.author | Choi, Se Hyun | - |
dc.contributor.author | Kim, Yu Jeong | - |
dc.contributor.author | Milner, Caroline M. | - |
dc.contributor.author | Day, Anthony J. | - |
dc.date.accessioned | 2022-05-16T08:51:18Z | - |
dc.date.available | 2022-05-16T08:51:18Z | - |
dc.date.created | 2022-04-14 | - |
dc.date.created | 2022-04-14 | - |
dc.date.created | 2022-04-14 | - |
dc.date.created | 2022-04-14 | - |
dc.date.created | 2022-04-14 | - |
dc.date.issued | 2022-04 | - |
dc.identifier.citation | Ocular Surface, Vol.24, pp.40-50 | - |
dc.identifier.issn | 1542-0124 | - |
dc.identifier.uri | https://hdl.handle.net/10371/179783 | - |
dc.description.abstract | © 2021 The AuthorsPurpose: To investigate the potential of the Link_TSG6 polypeptide comprising the Link module of human TSG-6 (TNF-stimulated gene/protein-6) as a novel treatment for dry eye disease (DED). Methods: We analyzed the therapeutic effects of topical application of Link_TSG6 in two murine models of DED, the NOD.B10.H2b mouse model and the desiccating stress model. The effects of Link_TSG6 on the ocular surface and DED were compared with those of full-length TSG-6 (FL_TSG6) and of 0.05% cyclosporine (Restasis®). Additionally, the direct effect of Link_TSG6 on wound healing of the corneal epithelium was evaluated in a mouse model of corneal epithelial debridement. Results: Topical Link_TSG6 administration dose-dependently reduced corneal epithelial defects in DED mice while increasing tear production and conjunctival goblet cell density. At the highest dose, no corneal lesions remained in ∼50% of eyes treated. Also, Link_TSG6 significantly suppressed the levels of inflammatory cytokines at the ocular surface and inhibited the infiltration of T cells in the lacrimal glands and draining lymph nodes. Link_TSG6 was more effective in decreasing corneal epithelial defects than an equimolar concentration of FL_TSG6. Link_TSG6 was significantly more potent than Restasis® at ameliorating clinical signs and reducing inflammation. Link_TSG6 markedly and rapidly facilitated epithelial healing in mice with corneal epithelial debridement wounds. Conclusion: Link_TSG6 holds promise as a novel therapeutic agent for DED through its effects on the promotion of corneal epithelial healing and tear secretion, the preservation of conjunctival goblet cells and the suppression of inflammation. | - |
dc.language | 영어 | - |
dc.publisher | Ethis Communications | - |
dc.title | The Link module of human TSG-6 (Link_TSG6) promotes wound healing, suppresses inflammation and improves glandular function in mouse models of Dry Eye Disease | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.jtos.2021.12.012 | - |
dc.citation.journaltitle | Ocular Surface | - |
dc.identifier.wosid | 000819919100007 | - |
dc.identifier.scopusid | 2-s2.0-85122508720 | - |
dc.citation.endpage | 50 | - |
dc.citation.startpage | 40 | - |
dc.citation.volume | 24 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Oh, Joo Youn | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | MESENCHYMAL STROMAL CELLS | - |
dc.subject.keywordPlus | INHIBITS NEUTROPHIL MIGRATION | - |
dc.subject.keywordPlus | THYMOSIN BETA 4 | - |
dc.subject.keywordPlus | STEM-CELLS | - |
dc.subject.keywordPlus | OCULAR SURFACE | - |
dc.subject.keywordPlus | MOLECULAR-MECHANISMS | - |
dc.subject.keywordPlus | STERILE INFLAMMATION | - |
dc.subject.keywordPlus | MURINE MODEL | - |
dc.subject.keywordPlus | T-CELLS | - |
dc.subject.keywordPlus | MACROPHAGE | - |
dc.subject.keywordAuthor | Dry eye disease | - |
dc.subject.keywordAuthor | Link module | - |
dc.subject.keywordAuthor | Link_TSG6 | - |
dc.subject.keywordAuthor | TNF-Stimulated gene/protein-6 | - |
dc.subject.keywordAuthor | TSG-6 | - |
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