Publications

Detailed Information

The Link module of human TSG-6 (Link_TSG6) promotes wound healing, suppresses inflammation and improves glandular function in mouse models of Dry Eye Disease

DC Field Value Language
dc.contributor.authorOh, Joo Youn-
dc.contributor.authorRyu, Jin Suk-
dc.contributor.authorKim, Hyeon Ji-
dc.contributor.authorKouvatsos, Nikolaos-
dc.contributor.authorDodd, Rebecca J.-
dc.contributor.authorChoi, Se Hyun-
dc.contributor.authorKim, Yu Jeong-
dc.contributor.authorMilner, Caroline M.-
dc.contributor.authorDay, Anthony J.-
dc.date.accessioned2022-05-16T08:51:18Z-
dc.date.available2022-05-16T08:51:18Z-
dc.date.created2022-04-14-
dc.date.created2022-04-14-
dc.date.created2022-04-14-
dc.date.created2022-04-14-
dc.date.created2022-04-14-
dc.date.issued2022-04-
dc.identifier.citationOcular Surface, Vol.24, pp.40-50-
dc.identifier.issn1542-0124-
dc.identifier.urihttps://hdl.handle.net/10371/179783-
dc.description.abstract© 2021 The AuthorsPurpose: To investigate the potential of the Link_TSG6 polypeptide comprising the Link module of human TSG-6 (TNF-stimulated gene/protein-6) as a novel treatment for dry eye disease (DED). Methods: We analyzed the therapeutic effects of topical application of Link_TSG6 in two murine models of DED, the NOD.B10.H2b mouse model and the desiccating stress model. The effects of Link_TSG6 on the ocular surface and DED were compared with those of full-length TSG-6 (FL_TSG6) and of 0.05% cyclosporine (Restasis®). Additionally, the direct effect of Link_TSG6 on wound healing of the corneal epithelium was evaluated in a mouse model of corneal epithelial debridement. Results: Topical Link_TSG6 administration dose-dependently reduced corneal epithelial defects in DED mice while increasing tear production and conjunctival goblet cell density. At the highest dose, no corneal lesions remained in ∼50% of eyes treated. Also, Link_TSG6 significantly suppressed the levels of inflammatory cytokines at the ocular surface and inhibited the infiltration of T cells in the lacrimal glands and draining lymph nodes. Link_TSG6 was more effective in decreasing corneal epithelial defects than an equimolar concentration of FL_TSG6. Link_TSG6 was significantly more potent than Restasis® at ameliorating clinical signs and reducing inflammation. Link_TSG6 markedly and rapidly facilitated epithelial healing in mice with corneal epithelial debridement wounds. Conclusion: Link_TSG6 holds promise as a novel therapeutic agent for DED through its effects on the promotion of corneal epithelial healing and tear secretion, the preservation of conjunctival goblet cells and the suppression of inflammation.-
dc.language영어-
dc.publisherEthis Communications-
dc.titleThe Link module of human TSG-6 (Link_TSG6) promotes wound healing, suppresses inflammation and improves glandular function in mouse models of Dry Eye Disease-
dc.typeArticle-
dc.identifier.doi10.1016/j.jtos.2021.12.012-
dc.citation.journaltitleOcular Surface-
dc.identifier.wosid000819919100007-
dc.identifier.scopusid2-s2.0-85122508720-
dc.citation.endpage50-
dc.citation.startpage40-
dc.citation.volume24-
dc.description.isOpenAccessY-
dc.contributor.affiliatedAuthorOh, Joo Youn-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.subject.keywordPlusMESENCHYMAL STROMAL CELLS-
dc.subject.keywordPlusINHIBITS NEUTROPHIL MIGRATION-
dc.subject.keywordPlusTHYMOSIN BETA 4-
dc.subject.keywordPlusSTEM-CELLS-
dc.subject.keywordPlusOCULAR SURFACE-
dc.subject.keywordPlusMOLECULAR-MECHANISMS-
dc.subject.keywordPlusSTERILE INFLAMMATION-
dc.subject.keywordPlusMURINE MODEL-
dc.subject.keywordPlusT-CELLS-
dc.subject.keywordPlusMACROPHAGE-
dc.subject.keywordAuthorDry eye disease-
dc.subject.keywordAuthorLink module-
dc.subject.keywordAuthorLink_TSG6-
dc.subject.keywordAuthorTNF-Stimulated gene/protein-6-
dc.subject.keywordAuthorTSG-6-
Appears in Collections:
Files in This Item:
There are no files associated with this item.

Related Researcher

  • College of Medicine
  • Department of Medicine
Research Area 각막 및 외안부 질환, 백내장

Altmetrics

Item View & Download Count

  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Share