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Enhanced Immunogenicity of Engineered HER2 Antigens Potentiates Antitumor Immune Responses
DC Field | Value | Language |
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dc.contributor.author | Jeon, Insu | - |
dc.contributor.author | Lee, Jeong-Mi | - |
dc.contributor.author | Shin, Kwang-Soo | - |
dc.contributor.author | Kang, Taeseung | - |
dc.contributor.author | Park, Myung Hwan | - |
dc.contributor.author | Seo, Hyungseok | - |
dc.contributor.author | Song, Boyeong | - |
dc.contributor.author | Koh, Choong-Hyun | - |
dc.contributor.author | Choi, Jeongwon | - |
dc.contributor.author | Shin, Young Kee | - |
dc.contributor.author | Kim, Byung-Seok | - |
dc.contributor.author | Kang, Chang-Yuil | - |
dc.date.accessioned | 2022-05-16T08:53:13Z | - |
dc.date.available | 2022-05-16T08:53:13Z | - |
dc.date.created | 2020-11-10 | - |
dc.date.created | 2020-11-10 | - |
dc.date.created | 2020-11-10 | - |
dc.date.created | 2020-11-10 | - |
dc.date.created | 2020-11-10 | - |
dc.date.created | 2020-11-10 | - |
dc.date.created | 2020-11-10 | - |
dc.date.issued | 2020-09 | - |
dc.identifier.citation | Vaccines, Vol.8 No.3, pp.403-17 | - |
dc.identifier.issn | 2076-393X | - |
dc.identifier.uri | https://hdl.handle.net/10371/179807 | - |
dc.description.abstract | For cancer vaccines, the selection of optimal tumor-associated antigens (TAAs) that can maximize the immunogenicity of the vaccine without causing unwanted adverse effects is challenging. In this study, we developed two engineered Human epidermal growth factor receptor 2 (HER2) antigens, K965 and K1117, and compared their immunogenicity to a previously reported truncated HER2 antigen, K684, within a B cell and monocyte-based vaccine (BVAC). We found that BVAC-K965 and BVAC-K1117 induced comparable antigen-specific antibody responses and antigen-specific T cell responses to BVAC-K684. Interestingly, BVAC-K1117 induced more potent antitumor activity than the other vaccines in murine CT26-HER2 tumor models. In addition, BVAC-K1117 showed enhanced antitumor effects against truncated p95HER2-expressing CT26 tumors compared to BVAC-K965 and BVAC-K684 based on the survival analysis by inducing T cell responses against intracellular domain (ICD) epitopes. The increased ICD epitope-specific T cell responses induced by BVAC-K1117 compared to BVAC-K965 and BVAC-K684 were recapitulated in human leukocyte antigen (HLA)-untyped human PBMCs and HLA-A*0201 PBMCs. Furthermore, we also observed synergistic antitumor effects between BVAC-K1117 and anti-PD-L1 antibody treatment against CT26-HER2 tumors. Collectively, our findings demonstrate that inclusion of a sufficient number of ICD epitopes of HER2 in cellular vaccines can improve the antitumor activity of the vaccine and provide a way to optimize the efficacy of anticancer cellular vaccines targeting HER2. | - |
dc.language | 영어 | - |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | - |
dc.title | Enhanced Immunogenicity of Engineered HER2 Antigens Potentiates Antitumor Immune Responses | - |
dc.type | Article | - |
dc.identifier.doi | 10.3390/vaccines8030403 | - |
dc.citation.journaltitle | Vaccines | - |
dc.identifier.wosid | 000581682100001 | - |
dc.identifier.scopusid | 2-s2.0-85088318155 | - |
dc.citation.endpage | 17 | - |
dc.citation.number | 3 | - |
dc.citation.startpage | 403 | - |
dc.citation.volume | 8 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Seo, Hyungseok | - |
dc.contributor.affiliatedAuthor | Shin, Young Kee | - |
dc.contributor.affiliatedAuthor | Kang, Chang-Yuil | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | CARBOXY-TERMINAL FRAGMENT | - |
dc.subject.keywordPlus | MAMMARY-TUMOR GROWTH | - |
dc.subject.keywordPlus | FULL-LENGTH | - |
dc.subject.keywordPlus | B-CELLS | - |
dc.subject.keywordPlus | T-CELLS | - |
dc.subject.keywordPlus | IMMUNODOMINANT PEPTIDE | - |
dc.subject.keywordPlus | THERAPEUTIC-EFFICACY | - |
dc.subject.keywordPlus | CARDIAC TOXICITY | - |
dc.subject.keywordPlus | IFN-GAMMA | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordAuthor | HER2 | - |
dc.subject.keywordAuthor | p95HER2 | - |
dc.subject.keywordAuthor | cancer vaccine | - |
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