Publications

Detailed Information

Fetal inflammatory response is positively correlated with the progress of inflammation in chorionic plate

DC Field Value Language
dc.contributor.authorOh, Jeong-Won-
dc.contributor.authorPark, Chan-Wook-
dc.contributor.authorMoon, Kyung Chul-
dc.contributor.authorPark, Joong Shin-
dc.contributor.authorJun, Jong Kwan-
dc.date.accessioned2022-05-20T00:44:47Z-
dc.date.available2022-05-20T00:44:47Z-
dc.date.created2020-10-14-
dc.date.created2020-10-14-
dc.date.created2020-10-14-
dc.date.created2020-10-14-
dc.date.created2020-10-14-
dc.date.issued2020-08-
dc.identifier.citationPlacenta, Vol.97, pp.6-17-
dc.identifier.issn0143-4004-
dc.identifier.urihttps://hdl.handle.net/10371/179893-
dc.description.abstractIntroduction: No information exists about the relationship among the progress of inflammation in chorionic-plate, fetal inflammatory response (FIR), funisitis, amnionitis and early-onset neonatal sepsis (EONS) in patients with either preterm labor or preterm premature rupture of membranes (preterm-PROM). The objective of current study is to examine this issue. Methods: Study population included 247 singleton preterm gestations (21.6 weeks <= gestational age at delivery <= 36 weeks) who had either preterm-labor or preterm-PROM with acute placental inflammation. We examined the intensity of FIR, and the frequency of fetal inflammatory response syndrome (FIRS), funisitis, amnionitis and proven or suspected EONS according to the progress of inflammation in chorionic-plate. The intensity of FIR was measured with umbilical cord plasma (UCP)-CRP concentration (ng/ml) at birth, and FIRS was defined as an elevated UCP-CRP concentration (>= 200 ng/ml). The progress of inflammation in chorionic-plate was divided with a slight modification from previously reported-criteria as follows: stage-0, inflammation-free chorionicplate; stage-1, inflammation restricted to subchorionic fibrin (SCF); stage-2, inflammation in the connective tissue (CT) of chorionic-plate without chorionic vasculitis; stage-3, chorionic vasculitis. Results: 1) Stage-0, stage-1, stage-2 and stage-3 of inflammation in chorionic-plate were present in 36.8% (91/247), 29.6% (73/247), 25.5% (63/247), and 8.1% (20/247) of cases; 2) UCP-CRP concentration at birth was significantly and positively correlated with the progress of inflammation in chorionic-plate (Spearman's rank correlation test, P<.000001, gamma = 0.391 and Kruskal-Wallis test, P<.001); 3) Moreover, FIRS, funisitis, amnionitis, and EONS were significantly more frequent as a function of the progress of inflammation in chorionic-plate. Discussion: The intensity of FIR and the frequency of FIRS were positively correlated with the progress of inflammation in chorionic-plate in patients with either PTL or preterm-PROM. This suggests chorionic-plate may be an independent compartment for the analysis of inflammation.-
dc.language영어-
dc.publisherW. B. Saunders Co., Ltd.-
dc.titleFetal inflammatory response is positively correlated with the progress of inflammation in chorionic plate-
dc.typeArticle-
dc.identifier.doi10.1016/j.placenta.2020.05.010-
dc.citation.journaltitlePlacenta-
dc.identifier.wosid000559965000002-
dc.identifier.scopusid2-s2.0-85086149881-
dc.citation.endpage17-
dc.citation.startpage6-
dc.citation.volume97-
dc.description.isOpenAccessY-
dc.contributor.affiliatedAuthorPark, Chan-Wook-
dc.contributor.affiliatedAuthorMoon, Kyung Chul-
dc.contributor.affiliatedAuthorPark, Joong Shin-
dc.contributor.affiliatedAuthorJun, Jong Kwan-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.subject.keywordPlusC-REACTIVE PROTEIN-
dc.subject.keywordPlusASCENDING INTRAUTERINE INFECTION-
dc.subject.keywordPlusBLOOD-CELL COUNT-
dc.subject.keywordPlusAMNIOTIC-FLUID-
dc.subject.keywordPlusHISTOLOGIC CHORIOAMNIONITIS-
dc.subject.keywordPlusUMBILICAL-CORD-
dc.subject.keywordPlusPLACENTAL INFLAMMATION-
dc.subject.keywordPlusPREMATURE RUPTURE-
dc.subject.keywordPlusPRETERM PLACENTA-
dc.subject.keywordPlusLESIONS-
dc.subject.keywordAuthorFIRS-
dc.subject.keywordAuthorFetal inflammatory response-
dc.subject.keywordAuthorChorionic plate inflammation-
dc.subject.keywordAuthorPreterm labor-
dc.subject.keywordAuthorPreterm-PROM-
Appears in Collections:
Files in This Item:
There are no files associated with this item.

Altmetrics

Item View & Download Count

  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Share