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Triple deletion of TP53, PCNT, and CEP215 promotes centriole amplification in the M phase
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jung, Gee In | - |
dc.contributor.author | Rhee, Kunsoo | - |
dc.date.accessioned | 2022-05-20T07:35:34Z | - |
dc.date.available | 2022-05-20T07:35:34Z | - |
dc.date.created | 2021-07-30 | - |
dc.date.created | 2021-07-30 | - |
dc.date.created | 2021-07-30 | - |
dc.date.issued | 2021-08 | - |
dc.identifier.citation | Cell Cycle, Vol.20 No.15, pp.1500-1517 | - |
dc.identifier.issn | 1538-4101 | - |
dc.identifier.uri | https://hdl.handle.net/10371/179970 | - |
dc.description.abstract | Supernumerary centrioles are frequently observed in diverse types of cancer cells. In this study, we investigated the mechanism underlying the generation of supernumerary centrioles during the M phase. We generated the TP53;PCNT;CEP215 triple knockout (KO) cells and determined the configurations of the centriole during the cell cycle. The triple KO cells exhibited a precocious separation of centrioles and unscheduled centriole assembly in the M phase. Supernumerary centrioles in the triple KO cells were present throughout the cell cycle; however, among all the centrioles, only two maintained an intact composition, including CEP135, CEP192, CEP295 and CEP152. Intact centrioles were formed during the S phase and the rest of the centrioles may be generated during the M phase. M-phase-assembled centrioles lacked the ability to organize microtubules in the interphase; however, a fraction of them may acquire pericentriolar material to organize microtubules during the M phase. Taken together, our work reveals the heterogeneity of the supernumerary centrioles in the triple KO cells. | - |
dc.language | 영어 | - |
dc.publisher | Landes Bioscience | - |
dc.title | Triple deletion of TP53, PCNT, and CEP215 promotes centriole amplification in the M phase | - |
dc.type | Article | - |
dc.identifier.doi | 10.1080/15384101.2021.1950386 | - |
dc.citation.journaltitle | Cell Cycle | - |
dc.identifier.wosid | 000670863800001 | - |
dc.identifier.scopusid | 2-s2.0-85109926867 | - |
dc.citation.endpage | 1517 | - |
dc.citation.number | 15 | - |
dc.citation.startpage | 1500 | - |
dc.citation.volume | 20 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Rhee, Kunsoo | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | CENTROSOME AMPLIFICATION | - |
dc.subject.keywordPlus | PLK4 | - |
dc.subject.keywordPlus | DUPLICATION | - |
dc.subject.keywordPlus | PERICENTRIN | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | CDK5RAP2 | - |
dc.subject.keywordPlus | RECRUITMENT | - |
dc.subject.keywordPlus | BIOGENESIS | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | DISENGAGEMENT | - |
dc.subject.keywordAuthor | Centrosome | - |
dc.subject.keywordAuthor | supernumerary centrioles | - |
dc.subject.keywordAuthor | cell cycle | - |
dc.subject.keywordAuthor | mitosis | - |
dc.subject.keywordAuthor | CEP215 | - |
dc.subject.keywordAuthor | PCNT | - |
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