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Cargo proteins in extracellular vesicles: potential for novel therapeutics in non-alcoholic steatohepatitis
Cited 13 time in
Web of Science
Cited 13 time in Scopus
- Authors
- Issue Date
- 2021-11
- Publisher
- BioMed Central
- Citation
- Journal of Nanobiotechnology, Vol.19 No.1, p. 372
- Abstract
- Background: Extracellular vesicles (EVs) are recognized as novel cell-free therapeutics. Non-alcoholic steatohepatitis (NASH) remains a critical health problem. Herein, we show that EVs from pan peroxisome proliferator-activated receptor agonist-primed induced mesenchymal stem cell (pan PPAR-iMSC-EVs) has unique cargo protein signatures, and demonstrate its therapeutic function in NASH. Results: A unique protein signatures were identified in pan PPAR-iMSC-EVs against those from non-stimulated iMSC-EVs. NASH mice receiving pan PPAR-iMSC-EVs showed reduced steatotic changes and ameliorated ER stress and mitochondiral oxidative stress induced by inflammation. Moreover, pan PPAR-iMSC-EVs promoted liver regeneration via inhibiting apoptosis and enhancing proliferation. Conclusions: We conclude that our strategy for enriching unique cargo proteins in EVs may facilitate the development of novel therapeutic option for NASH.
- ISSN
- 1477-3155
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