Publications
Detailed Information
Response prediction of vestibular schwannoma after gamma-knife radiosurgery using pretreatment dynamic contrast-enhanced MRI: a prospective study
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hwang, Inpyeong | - |
dc.contributor.author | Choi, Seung Hong | - |
dc.contributor.author | Kim, Jin Wook | - |
dc.contributor.author | Yeon, Eung Koo | - |
dc.contributor.author | Lee, Ji Ye | - |
dc.contributor.author | Yoo, Roh-Eul | - |
dc.contributor.author | Kang, Koung Mi | - |
dc.contributor.author | Yun, Tae Jin | - |
dc.contributor.author | Kim, Ji-hoon | - |
dc.contributor.author | Sohn, Chul-ho | - |
dc.date.accessioned | 2022-06-21T06:51:52Z | - |
dc.date.available | 2022-06-21T06:51:52Z | - |
dc.date.created | 2022-05-13 | - |
dc.date.issued | 2022-06 | - |
dc.identifier.citation | European Radiology, Vol.32 No.6, pp.3734-3743 | - |
dc.identifier.issn | 0938-7994 | - |
dc.identifier.uri | https://hdl.handle.net/10371/182587 | - |
dc.description.abstract | © 2022, The Author(s), under exclusive licence to European Society of Radiology.Objectives: There are few known predictive factors for response to gamma-knife radiosurgery (GKRS) in vestibular schwannoma (VS). We investigated the predictive role of pretreatment dynamic contrast-enhanced (DCE)-MRI parameters regarding the tumor response after GKRS in sporadic VS. Methods: This single-center prospective study enrolled participants between April 2017 and February 2019. We performed a volumetric measurement of DCE-MRI-derived parameters before GKRS. The tumor volume was measured in a follow-up MRI. The pharmacokinetic parameters were compared between responders and nonresponders according to 20% or more tumor volume reduction. Stepwise multivariable logistic regression analyses were performed, and the diagnostic performance of DCE-MRI parameters for the prediction of tumor response was evaluated by receiver operating characteristic curve analysis. Results: Ultimately, 35 participants (21 women, 52 ± 12 years) were included. There were 22 (62.9%) responders with a mean follow-up interval of 30.2 ± 5.7 months. Ktrans (0.036 min−1 vs. 0.057 min−1, p =.008) and initial area under the time-concentration curve within 90 s (IAUC90) (84.4 vs. 143.6, p =.003) showed significant differences between responders and nonresponders. Ktrans (OR = 0.96, p =.021) and IAUC90 (OR = 0.97, p =.004) were significant differentiating variables in each multivariable model with clinical variables for tumor response prediction. Ktrans showed a sensitivity of 81.8% and a specificity of 69.2%, and IAUC90 showed a sensitivity of 100% and a specificity of 53.8% for tumor response prediction. Conclusion: DCE-MRI (particularly Ktrans and IAUC90) has the potential to be a predictive factor for tumor response in VS after GKRS. Key Points: •Pretreatment prediction of gamma-knife radiosurgery response in vestibular schwannoma is still challenging. •Dynamic contrast-enhanced MRI could have predictive value for the response of vestibular schwannoma after gamma-knife radiosurgery. | - |
dc.language | 영어 | - |
dc.publisher | Springer Verlag | - |
dc.title | Response prediction of vestibular schwannoma after gamma-knife radiosurgery using pretreatment dynamic contrast-enhanced MRI: a prospective study | - |
dc.type | Article | - |
dc.identifier.doi | 10.1007/s00330-021-08517-1 | - |
dc.citation.journaltitle | European Radiology | - |
dc.identifier.wosid | 000749072100001 | - |
dc.identifier.scopusid | 2-s2.0-85123954287 | - |
dc.citation.endpage | 3743 | - |
dc.citation.number | 6 | - |
dc.citation.startpage | 3734 | - |
dc.citation.volume | 32 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Choi, Seung Hong | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.