Publications
Detailed Information
Hamuramicin C, a Cytotoxic Bicyclic Macrolide Isolated from a Wasp Gut Bacterium
DC Field | Value | Language |
---|---|---|
dc.contributor.author | An, Joon Soo | - |
dc.contributor.author | Lim, Hyung-Ju | - |
dc.contributor.author | Lee, Ji Yun | - |
dc.contributor.author | Jang, Yong-Joon | - |
dc.contributor.author | Nam, Sang-Jip | - |
dc.contributor.author | Lee, Sang Kook | - |
dc.contributor.author | Oh, Dong-Chan | - |
dc.date.accessioned | 2022-06-22T04:05:38Z | - |
dc.date.available | 2022-06-22T04:05:38Z | - |
dc.date.created | 2022-05-24 | - |
dc.date.issued | 2022-04 | - |
dc.identifier.citation | Journal of Natural Products, Vol.85 No.4, pp.936-942 | - |
dc.identifier.issn | 0163-3864 | - |
dc.identifier.uri | https://hdl.handle.net/10371/182769 | - |
dc.description.abstract | A new bicyclic macrolide, hamuramicin C (1), was isolated from Streptomyces sp. MBP16, a gut bacterial strain of the wasp Vespa crabro flavofasciata. Its 22-membered macrocyclic lactone structure was determined by NMR and mass spectrometry. The relative configurations of hamuramicin C (1) were assigned by J-based configuration analysis utilizing H-1 rotating frame Overhauser effect spectroscopy and heteronuclear long-range coupling NMR spectroscopy. Genomic and bioinformatic analyses of the bacterial strain enabled identification of the type-I polyketide synthase pathway, which employs a trans-acyltransferase system. The absolute configurations of 1 were proposed based on the analysis of the sequences of ketoreductases in the modular gene cluster. Moreover, hamuramicin C (1) demonstrated significant inhibitory activity against diverse human cancer cell lines (HCT116, A549, SNU-638, SK-HEP-1, and MDA-MB-231). | - |
dc.language | 영어 | - |
dc.publisher | American Chemical Society | - |
dc.title | Hamuramicin C, a Cytotoxic Bicyclic Macrolide Isolated from a Wasp Gut Bacterium | - |
dc.type | Article | - |
dc.identifier.doi | 10.1021/acs.jnatprod.1c01075 | - |
dc.citation.journaltitle | Journal of Natural Products | - |
dc.identifier.wosid | 000791431400018 | - |
dc.identifier.scopusid | 2-s2.0-85128219766 | - |
dc.citation.endpage | 942 | - |
dc.citation.number | 4 | - |
dc.citation.startpage | 936 | - |
dc.citation.volume | 85 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Lee, Sang Kook | - |
dc.contributor.affiliatedAuthor | Oh, Dong-Chan | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.