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Nyuzenamide C, an Antiangiogenic Epoxy Cinnamic Acid-Containing Bicyclic Peptide from a Riverine Streptomyces sp.
DC Field | Value | Language |
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dc.contributor.author | An, Joon Soo | - |
dc.contributor.author | Kim, Myoun-Su | - |
dc.contributor.author | Han, Jaeho | - |
dc.contributor.author | Jang, Sung Chul | - |
dc.contributor.author | Im, Ji Hyeon | - |
dc.contributor.author | Cui, Jinsheng | - |
dc.contributor.author | Lee, Yeonjin | - |
dc.contributor.author | Nam, Sang-Jip | - |
dc.contributor.author | Shin, Jongheon | - |
dc.contributor.author | Lee, Sang Kook | - |
dc.contributor.author | Yoon, Yeo Joon | - |
dc.contributor.author | Oh, Dong-Chan | - |
dc.date.accessioned | 2022-06-22T04:05:39Z | - |
dc.date.available | 2022-06-22T04:05:39Z | - |
dc.date.created | 2022-05-24 | - |
dc.date.issued | 2022-04 | - |
dc.identifier.citation | Journal of Natural Products, Vol.85 No.4, pp.804-814 | - |
dc.identifier.issn | 0163-3864 | - |
dc.identifier.uri | https://hdl.handle.net/10371/182770 | - |
dc.description.abstract | A new nonribosomal peptide, nyuzenamide C (1), was discovered from riverine sediment-derived Streptomyces sp. DM14. Comprehensive analysis of the spectroscopic data of nyuzenamide C (1) revealed that 1 has a bicyclic backbone composed of six common amino acid residues (Asn, Leu, Pro, Gly, Val, and Thr) and four nonproteinogenic amino acid units, including hydroxyglycine, beta-hydroxyphenylalanine, p-hydroxyphenylglycine, and 3,beta-dihydroxytyrosine, along with 1,2-epoxypropyl cinnamic acid. The absolute configuration of 1 was proposed by J-based configuration analysis, the advanced Marfey's method, quantum mechanics-based DP4 calculations, and bioinformatic analysis of its nonribosomal peptide synthetase biosynthetic gene cluster. Nyuzenamide C (1) displayed antiangiogenic activity in human umbilical vein endothelial cells and induced quinone reductase in murine Hepa-1c1c7 cells. | - |
dc.language | 영어 | - |
dc.publisher | American Chemical Society | - |
dc.title | Nyuzenamide C, an Antiangiogenic Epoxy Cinnamic Acid-Containing Bicyclic Peptide from a Riverine Streptomyces sp. | - |
dc.type | Article | - |
dc.identifier.doi | 10.1021/acs.jnatprod.1c00837 | - |
dc.citation.journaltitle | Journal of Natural Products | - |
dc.identifier.wosid | 000791431400005 | - |
dc.identifier.scopusid | 2-s2.0-85127267245 | - |
dc.citation.endpage | 814 | - |
dc.citation.number | 4 | - |
dc.citation.startpage | 804 | - |
dc.citation.volume | 85 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Shin, Jongheon | - |
dc.contributor.affiliatedAuthor | Lee, Sang Kook | - |
dc.contributor.affiliatedAuthor | Yoon, Yeo Joon | - |
dc.contributor.affiliatedAuthor | Oh, Dong-Chan | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
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