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Long-term Outcomes of Gamma Knife Stereotactic Radiosurgery of Vestibular Schwannomas

Cited 17 time in Web of Science Cited 0 time in Scopus
Authors
Kim, Kang-Min; Park, Chul-Kee; Chung, Hyun-Tai; Paek, Sun Ha; Jung, Hee-Won; Kim, Dong Gyu
Issue Date
2007-10-01
Publisher
The Korean Neurosurgical Society
Citation
J Korean Neurosurg Soc. 2007 Oct;42(4):286-92. Epub 2007 Oct 20.
Abstract
OBJECTIVE: Gamma Knife Stereotactic Radiosurgery (GK SRS) has become an important treatment modality for vestibular schwannomas. We evaluated the tumor control rate, patterns of tumor volume change and preservation of hearing following low-dose radiation for vestibular schwannomas in a homogeneous cohort group in which the mean marginal dose was 12 Gy. METHODS: A total of 59 patients were enrolled in this study. All enrolled patients were followed-up for at least 5 years and the radiation dose was 11-13 Gy. Regular MRI, audiometry and clinical evaluations were done and tumor volumes were obtained from MRI using the OSIRIS program. RESULTS: The tumor control rate was 97%. We were able to classify the patterns of change in tumor volume into three categories. Transient increases in tumor volume were detected in 29% of the patients and the maximum transient increase in tumor volume was identified at 6 to 30 months after GK SRS. The transient increases in tumor volume ranged from 121% to 188%. Hearing was preserved in 4 of the 12 patients who had serviceable hearing prior to treatment. There were no other complications associated with GK SRS. CONCLUSION: Low-dose GK SRS was an effective and safe mode of treatment for vestibular schwannomas in comparison to the previously used high-dose GK SRS. Transient increases in tumor volume can be identified during the follow-up period after low-dose GK SRS for vestibular schwannomas. Physicians should be aware that these increases are not always indicative of treatment failure and that close observation is required following treatments. Unfortunately, a satisfactory hearing preservation rate was not achieved by reducing the radiation dose. It is thought that hearing preservation is a more sophisticated problem and further research is required.
ISSN
2005-3711 (Print)
Language
English
URI
http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=19096558

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19096558

http://hdl.handle.net/10371/18296
DOI
https://doi.org/10.3340/jkns.2007.42.4.286
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College of Medicine/School of Medicine (의과대학/대학원)Neurosurgery (신경외과학전공)Journal Papers (저널논문_신경외과학전공)
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