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Survival in Korean Patients with Frontotemporal Dementia Syndrome: Association with Behavioral Features and Parkinsonism

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Jung, Na-Yeon; Park, Kee Hyung; Seo, Sang Won; Kim, Hee Jin; Roh, Jee Hoon; Lee, Jae-Hong; Park, Kyung Won; Kwon, Jay C.; Jeong, Jee Hyang; Yoon, Soo Jin; Kim, Byeong C.; Park, Young Ho; Kim, SangYun; Jang, Jae-Won; Youn, Young Chul; Yang, Dong Won; Choi, Seong Hye; Na, Duk L.; Kim, Eun-Joo

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Journal of Clinical Medicine, Vol.11 No.8
We investigated the survival time of each clinical syndrome of frontotemporal dementia (FTD) and the impacts of behavioral and motor features on survival of FTD. A total of 216 patients with FTD [82 behavioral variant FTD (bvFTD), 78 semantic variant primary progressive aphasia (svPPA), 43 non-fluent/agrammatic variant PPA (nfvPPA), 13 FTD-motor neuron disease (MND)] were enrolled from 16 centers across Korea. Behaviors and parkinsonism were assessed using the Frontal Behavioral Inventory and Unified Parkinson's Disease Rating Scale Part III, respectively. The Kaplan-Meier method was used for the survival analysis and the Cox proportional hazards model was applied for analysis of the effect of behavioral and motor symptoms on survival, after controlling vascular risk factors and cancer. An overall median survival of FTD was 12.1 years. The survival time from onset was shortest for FTD-MND and longest for svPPA. The median survival time of patients with bvFTD was unavailable but likely comparable to that of patients with nfvPPA. In the bvFTD group, negative behavioral symptoms and akinetic rigidity were significantly associated with survival. In the nfvPPA group, the presence of dysarthria had a negative impact on survival. These findings provide useful information to clinicians planning for care.
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