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Raman Thermometry Nanopipettes in Cancer Photothermal Therapy
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Dinh Nghi Ngo | - |
dc.contributor.author | Vuong Thi Thanh Xuan Ho | - |
dc.contributor.author | Kim, Gun | - |
dc.contributor.author | Song, Min Seok | - |
dc.contributor.author | Kim, Mi Ri | - |
dc.contributor.author | Choo, Jaebum | - |
dc.contributor.author | Joo, Sang-Woo | - |
dc.contributor.author | Lee, So Yeong | - |
dc.date.accessioned | 2022-06-22T11:15:09Z | - |
dc.date.available | 2022-06-22T11:15:09Z | - |
dc.date.created | 2022-05-31 | - |
dc.date.issued | 2022-05 | - |
dc.identifier.citation | Analytical Chemistry, Vol.94 No.17, pp.6463-6472 | - |
dc.identifier.issn | 0003-2700 | - |
dc.identifier.uri | https://hdl.handle.net/10371/183189 | - |
dc.description.abstract | Raman thermometry based on surface-enhanced Raman scattering has been developed using nanopipettes in cancer cell photothermal therapy (PTT). Gold nanorods (AuNRs) are robustly epoxied on glass pipettes with a high surface coverage of similar to 95% and less than 10 nm-wide nanogaps for intracellular thermometry and photothermal cancer therapy. The temperature changes could be estimated from the N equivalent to C band shifts of 4-fluorophenyl isocyanide (FPNC)-adsorbed AuNRs on the Raman thermometry nanopipette (RTN) surfaces. An intracellular temperature change of similar to 2.7 degrees C produced by altering the [Ca2+] in A431 cells was detected using the RTN in vitro, as checked from fura-2 acetoxymethyl ester (fura-2 AM) fluorescence images. For in vivo experiments, local temperature rises of similar to 19.2 degrees C were observed in the mouse skin, whereas infrared camera images could not tract due to spatial resolution. In addition, a tumor growth suppression was observed in the PTT processes after an administration of the three AuNR-coated nanopipettes combined with a 671 nm laser irradiation for 5 min in 30 days. These results demonstrate not only the localized temperature sensing ability of FPNC-tagged AuNR nanopipettes in cell biology but also anti-cancer effects in photothermal cancer therapy. | - |
dc.language | 영어 | - |
dc.publisher | American Chemical Society | - |
dc.title | Raman Thermometry Nanopipettes in Cancer Photothermal Therapy | - |
dc.type | Article | - |
dc.identifier.doi | 10.1021/acs.analchem.1c04452 | - |
dc.citation.journaltitle | Analytical Chemistry | - |
dc.identifier.wosid | 000795715700008 | - |
dc.identifier.scopusid | 2-s2.0-85128819169 | - |
dc.citation.endpage | 6472 | - |
dc.citation.number | 17 | - |
dc.citation.startpage | 6463 | - |
dc.citation.volume | 94 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Lee, So Yeong | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
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