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Association between patient age, microcirculation, and coronary stenosis assessment with fractional flow reserve and instantaneous wave-free ratio
DC Field | Value | Language |
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dc.contributor.author | Mejia-Renteria, Hernan | - |
dc.contributor.author | Faria, Daniel | - |
dc.contributor.author | Lee, Joo Myung | - |
dc.contributor.author | Lee, Seung Hun | - |
dc.contributor.author | Jung, Ji-Hyun | - |
dc.contributor.author | Doh, Joon-Hyung | - |
dc.contributor.author | Nam, Chang-Wook | - |
dc.contributor.author | Shin, Eun-Seok | - |
dc.contributor.author | Hoshino, Masahiro | - |
dc.contributor.author | Sugiyama, Tomoyo | - |
dc.contributor.author | Kanaji, Yoshihisa | - |
dc.contributor.author | Gonzalo, Nieves | - |
dc.contributor.author | Kakuta, Tsunekazu | - |
dc.contributor.author | Koo, Bon-Kwon | - |
dc.contributor.author | Escaned, Javier | - |
dc.date.accessioned | 2022-06-24T00:27:28Z | - |
dc.date.available | 2022-06-24T00:27:28Z | - |
dc.date.created | 2022-05-13 | - |
dc.date.issued | 2022-03 | - |
dc.identifier.citation | Catheterization and Cardiovascular Interventions, Vol.99 No.4, pp.1104-1114 | - |
dc.identifier.issn | 1522-1946 | - |
dc.identifier.uri | https://hdl.handle.net/10371/183810 | - |
dc.description.abstract | © 2022 Wiley Periodicals LLCObjectives: To investigate the effect of aging on coronary stenosis functional assessment with fractional flow reserve (FFR) and instantaneous wave-free ratio (iFR). Background: Limited data exist regarding the impact of patient age on these coronary pressure indices. Methods: We analyzed 514 patients with coronary stenosis interrogated with intravascular physiology. The influence of patient age on FFR, iFR, and microcirculation-related indices was investigated. Vessel-oriented composite outcome (VOCO) was assessed in the FFR-based deferred population according to iFR, coronary flow reserve (CFR), and age. Results: FFR increased (r = 0.128, p = 0.004), iFR remained unchanged (r = −0.001, p = 0.980), and CFR decreased (r = −0.095, p = 0.001) with patient age. Relationship between FFR and CFR differed across age groups (r = 0.263 in <60 years old vs. r = 0.124 in ≥60 years old, p = 0.0056), whereas iFR correlated to CFR similarly regardless age (r = 0.283 in <60 years old vs. r = 0.219 in ≥60 years old, p = 0.3781). No differences were found on angiographic stenosis severity (%DS 47.4 in <60 years old and 49.8 in ≥60 years old, p = 0.317). At 5 years, FFR-based revascularisation deferral in patients ≥60 years old was associated with more VOCO when either iFR (25%) or CFR (16.9%) were abnormal, compared to patients with normal iFR (6.3%) or normal CFR (4.6%) (log-rank p < 0.001). This difference in clinical outcomes was not observed in younger patients. Conclusions: FFR values increased progressively with patient age, potentially associated with age-related changes in the coronary microcirculation. Conversely, iFR values remained unchanged across the patient age spectrum. In ≥60 years old patients with revascularisation deferral based on FFR, both abnormal iFR and CFR values were associated with worse long-term patient outcomes. | - |
dc.language | 영어 | - |
dc.publisher | John Wiley & Sons Inc. | - |
dc.title | Association between patient age, microcirculation, and coronary stenosis assessment with fractional flow reserve and instantaneous wave-free ratio | - |
dc.type | Article | - |
dc.identifier.doi | 10.1002/ccd.30092 | - |
dc.citation.journaltitle | Catheterization and Cardiovascular Interventions | - |
dc.identifier.wosid | 000745628600001 | - |
dc.identifier.scopusid | 2-s2.0-85123475666 | - |
dc.citation.endpage | 1114 | - |
dc.citation.number | 4 | - |
dc.citation.startpage | 1104 | - |
dc.citation.volume | 99 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Koo, Bon-Kwon | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
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