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Association between serum uric acid and α-klotho protein levels in the middle-aged population
DC Field | Value | Language |
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dc.contributor.author | Lee, Hyo-Jung | - |
dc.contributor.author | Choi, Ju-Young | - |
dc.contributor.author | Lee, Jaeho | - |
dc.contributor.author | Kim, Donghoon | - |
dc.contributor.author | Min, Jin-Young | - |
dc.contributor.author | Min, Kyoung-Bok | - |
dc.date.accessioned | 2022-06-24T00:27:46Z | - |
dc.date.available | 2022-06-24T00:27:46Z | - |
dc.date.created | 2022-05-06 | - |
dc.date.issued | 2022-03 | - |
dc.identifier.citation | Aging-US, Vol.14 No.6, pp.2537-2547 | - |
dc.identifier.issn | 1945-4589 | - |
dc.identifier.uri | https://hdl.handle.net/10371/183828 | - |
dc.description.abstract | This study investigated the association between hyperuricemia and serum klotho protein levels in a representative sample of adults in the United States. We included 11,734 adults aged 40-80 years with available data of serum klotho, uric acid, covariates related to demographics, health behavior-related variables, and medical histories. Hyperuricemia was defined as a serum uric acid level of >= 7.0 mg/dL in men and >= 6.0 mg/dL in women. The geometric mean of serum klotho was 806.5 pg/mL (95% confidence interval: 801.7-811.4). The log-klotho level was negatively correlated with the uric acid level (r = -0.154; p < 0.0001). After adjustment for potential covariates, each one-unit increase in uric acid was significantly associated with a decrease in the log-klotho level (adjusted beta = -0.028; p < 0.0001). Compared with subjects without hyperuricemia, those with hyperuricemia had significantly lower serum klotho levels (adjusted beta = -0.062; p < 0.0001). We found a significant inverse association between serum uric acid and serum klotho levels in the general population, that is, an increase in serum uric acid levels was associated with a decrease in klotho levels. This finding suggests that loss of klotho may be due to the progression of hyperuricemia or, subsequently, gout. | - |
dc.language | 영어 | - |
dc.publisher | Impact Journals, LLC | - |
dc.title | Association between serum uric acid and α-klotho protein levels in the middle-aged population | - |
dc.type | Article | - |
dc.citation.journaltitle | Aging-US | - |
dc.identifier.wosid | 000782645200010 | - |
dc.identifier.scopusid | 2-s2.0-85128245247 | - |
dc.citation.endpage | 2547 | - |
dc.citation.number | 6 | - |
dc.citation.startpage | 2537 | - |
dc.citation.volume | 14 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Min, Kyoung-Bok | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
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