Publications

Detailed Information

Clinico-radiological characteristics of anti-myelin oligodendrocyte glycoprotein antibody-associated autoimmune encephalitis in children

Cited 3 time in Web of Science Cited 6 time in Scopus
Authors

Han, Ji Yeon; Kim, Soo Yeon; Kim, Hunmin; Hwang, Hee; Choi, Jieun; Chae, Jong-Hee; Kim, Ki Joong; Cheon, Jung-Eun; Lim, Byung Chan

Issue Date
2022-01
Publisher
Mac Keith Press
Citation
Developmental Medicine and Child Neurology
Abstract
© 2022 Mac Keith PressAim: To investigate the clinical characteristics and prevalence of paediatric anti-myelin oligodendrocyte glycoprotein (MOG) antibody-associated autoimmune encephalitis. Method: A total of 94 paediatric patients (46 males, 48 females, median age 9 years 5 months, range: 8 months–17 years 8 months) with autoimmune encephalitis were recruited at Seoul National University Childrens Hospital. We evaluated autoantibody status and identified patients with anti-MOG antibody-associated autoimmune encephalitis. Retrospective reviews of medical records were performed to describe clinical presentations, laboratory findings, treatments, and outcomes. Results: Eight patients (five males, three females, median age 11 years 9 months) with anti-MOG antibody-associated encephalitis were identified (8.5% of those with autoimmune encephalitis), one of whom was copositive for anti-N-methyl-d-aspartate receptor (NMDAR) antibodies. Anti-NMDAR antibodies were identified in 23 patients (23 out of 94, 24.5%). Unilateral or bilateral cortical involvement was identified in five patients. Focal contrast enhancement was also identified in three of the five patients with cortical lesions. All patients showed favourable response to immunotherapy with a Modified Rankin Scale ≤2 at the last follow-up. Relapse was found in one patient and clinico-radiological remission was achieved with cyclic intravenous immunoglobulin therapy. Interpretation: Anti-MOG antibody-associated encephalitis accounts for a significant proportion of clinically defined paediatric patients with autoimmune encephalitis. Anti-MOG antibody-associated encephalitis should be included in the clinical spectrum of anti-MOG-associated diseases.
ISSN
0012-1622
URI
https://hdl.handle.net/10371/183832
DOI
https://doi.org/10.1111/dmcn.15174
Files in This Item:
There are no files associated with this item.
Appears in Collections:

Altmetrics

Item View & Download Count

  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Share