Browse

Phospholipase Signaling in Breast Cancer

DC Field Value Language
dc.contributor.authorLee, Yu Jin-
dc.contributor.authorShin, Kyeong Jin-
dc.contributor.authorJang, Hyun-Jun-
dc.contributor.authorNoh, Dong-Young-
dc.contributor.authorRyu, Sung Ho-
dc.contributor.authorSuh, Pann-Ghill-
dc.date.accessioned2022-06-24T00:28:00Z-
dc.date.available2022-06-24T00:28:00Z-
dc.date.created2022-05-25-
dc.date.issued2021-
dc.identifier.citationAdvances in Experimental Medicine and Biology, Vol.1187, pp.23-52-
dc.identifier.issn0065-2598-
dc.identifier.urihttps://hdl.handle.net/10371/183847-
dc.description.abstractBreast cancer progression results from subversion of multiple intra- or intercellular signaling pathways in normal mammary tissues and their microenvironment, which have an impact on cell differentiation, proliferation, migration, and angiogenesis. Phospholipases (PLC, PLD and PLA) are essential mediators of intraand intercellular signaling. They hydrolyze phospholipids, which are major components of cell membrane that can generate many bioactive lipid mediators, such as diacylglycerol, phosphatidic acid, lysophosphatidic acid, and arachidonic acid. Enzymatic processing of phospholipids by phospholipases converts these molecules into lipid mediators that regulate multiple cellular processes, which in turn can promote breast cancer progression. Thus, dysregulation of phospholipases contributes to a number of human diseases, including cancer. This review describes how phospholipases regulate multiple cancer-associated cellular processes, and the interplay among different phospholipases in breast cancer. A thorough understanding of the breast cancer-associated signaling networks of phospholipases is necessary to determine whether these enzymes are potential targets for innovative therapeutic strategies.-
dc.language영어-
dc.publisherKluwer Academic/Plenum Publishers-
dc.titlePhospholipase Signaling in Breast Cancer-
dc.typeArticle-
dc.citation.journaltitleAdvances in Experimental Medicine and Biology-
dc.identifier.wosid000754424800002-
dc.identifier.scopusid2-s2.0-85105842501-
dc.citation.endpage52-
dc.citation.startpage23-
dc.citation.volume1187-
dc.identifier.rimsid162510-
dc.description.isOpenAccessN-
dc.contributor.affiliatedAuthorNoh, Dong-Young-
dc.type.rimsART-
dc.type.docTypeArticle; Book Chapter-
dc.description.journalClass1-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)Journal Papers (저널논문_의학과)
College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)Journal Papers (저널논문_의학과)
Files in This Item:
There are no files associated with this item.
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse