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Earlier-Phased Cancer Immunity Cycle Strongly Influences Cancer Immunity in Operable Never-Smoker Lung Adenocarcinoma
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Hong Kwan | - |
dc.contributor.author | Joung, Je-Gun | - |
dc.contributor.author | Choi, Yoon-La | - |
dc.contributor.author | Lee, Se-Hoon | - |
dc.contributor.author | Park, Byung Jo | - |
dc.contributor.author | Choi, Yong Soo | - |
dc.contributor.author | Ryu, Daeun | - |
dc.contributor.author | Nam, Jae-Yong | - |
dc.contributor.author | Lee, Mi-Sook | - |
dc.contributor.author | Park, Woong-Yang | - |
dc.contributor.author | Hwang, Soohyun | - |
dc.contributor.author | Cha, Hongui | - |
dc.contributor.author | Kim, Hong Sook | - |
dc.contributor.author | Lee, Sanghyuk | - |
dc.contributor.author | Jung, Yeonjoo | - |
dc.contributor.author | Lee, Jong Eun | - |
dc.contributor.author | Doh, Junsang | - |
dc.contributor.author | Paik, Soonmyung | - |
dc.contributor.author | Kang, Jung Hee | - |
dc.contributor.author | Lee, Jinseon | - |
dc.contributor.author | Kim, Jhingook | - |
dc.date.accessioned | 2022-06-24T00:28:52Z | - |
dc.date.available | 2022-06-24T00:28:52Z | - |
dc.date.created | 2020-09-25 | - |
dc.date.created | 2020-09-25 | - |
dc.date.issued | 2020-08 | - |
dc.identifier.citation | iScience, Vol.23 No.8, p. 101386 | - |
dc.identifier.issn | 2589-0042 | - |
dc.identifier.uri | https://hdl.handle.net/10371/183873 | - |
dc.description.abstract | Exome and transcriptome analyses of clinically homogeneous early-stage never -smoker female patients with lung adenocarcinoma were performed to under-stand tumor-T cell interactions and immune escape points. Using our novel gene panels of eight functional categories in the cancer-immunity cycle, three distinct subgroups were identified in this immune checkpoint blockade-refractory cohort by defective gene expression in two major domains, i.e., type I interferon production/signaling pathway and antigen-presenting machinery. Our approach could play a critical role in understanding immune evasion mechanisms, devel-oping a method for effective selection of rare immune checkpoint blockade re-sponders, and finding new treatment strategies. | - |
dc.language | 영어 | - |
dc.publisher | Cell Press | - |
dc.title | Earlier-Phased Cancer Immunity Cycle Strongly Influences Cancer Immunity in Operable Never-Smoker Lung Adenocarcinoma | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.isci.2020.101386 | - |
dc.citation.journaltitle | iScience | - |
dc.identifier.wosid | 000564154400003 | - |
dc.identifier.scopusid | 2-s2.0-85089278869 | - |
dc.citation.number | 8 | - |
dc.citation.startpage | 101386 | - |
dc.citation.volume | 23 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Doh, Junsang | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | CD4 T-CELLS | - |
dc.subject.keywordPlus | PD-1 BLOCKADE | - |
dc.subject.keywordPlus | LANDSCAPE | - |
dc.subject.keywordPlus | SECRETION | - |
dc.subject.keywordPlus | TUMORS | - |
dc.subject.keywordPlus | SENSITIVITY | - |
dc.subject.keywordAuthor | Cancer Systems Biology | - |
dc.subject.keywordAuthor | Genomics | - |
dc.subject.keywordAuthor | Immunology | - |
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